mProX™ Human PAK3 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PAK3 (p21-activated kinase 3) has various applications in different areas. In one study, a splicing variant of the PAK3 gene was found to be associated with X-linked intellectual disability in a child, expanding the understanding of genetic causes and providing a basis for genetic counseling and prenatal diagnosis. Another study showed that EZH2, a neuronal histone methyltransferase, regulates genes related to neuronal morphogenesis, including the gene encoding PAK3, which is important for dendritic spine density and cognitive behavior. Additionally, PAK3 was found to be involved in cardiac dysfunction, with its overexpression leading to pathological remodeling and deteriorated heart function. Targeting PAK3 has potential therapeutic implications for metastatic prostate cancer by addressing cell survival, proliferation, and motility. Lastly, HBV DNA integration into the human genome was shown to upregulate PAK3 expression, suggesting its involvement in hepatocarcinogenesis. These findings highlight the diverse roles of PAK3 in intellectual disabilities, neuronal morphogenesis, cardiac dysfunction, cancer, and hepatocellular carcinoma.