mProX™ Human PAK2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PAK2, also known as p21-activated kinase 2, is a gene that plays a role in various biological processes and has been implicated in different conditions. In a case report, PAK2 gene involvement was observed in a neonate with purpura fulminans and retinal detachment. Another study found that puerarin, a traditional Chinese medicine, inhibits bladder urothelial carcinoma cell proliferation and migration through the upregulation of PAK2, among other genes. Gastrodin, another natural compound, was found to ameliorate cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation. In adnexal skin tumors, including poroma and porocarcinoma, recurrent gene fusions involving PAK2 were identified, suggesting the potential role of PAK2 in the diagnosis and prognosis of these tumors. Finally, a cross-species analysis identified mitochondrial dysregulation, including PAK2 involvement, as a functional consequence of the 3q29 deletion, a genetic risk factor for schizophrenia. These findings highlight the diverse applications of PAK2 in various conditions and provide insights into its biological significance.