mProX™ Human PAK2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX416	Magic™ Human PAK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;AsPC-1

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research;Ocular Research

Related Diseases

Knobloch Syndrome 2; Knobloch Syndrome

Gene ID

Human:5062

UniProt ID

Human:Q13177

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PAK2, also known as p21-activated kinase 2, is a gene that plays a role in various biological processes and has been implicated in different conditions. In a case report, PAK2 gene involvement was observed in a neonate with purpura fulminans and retinal detachment. Another study found that puerarin, a traditional Chinese medicine, inhibits bladder urothelial carcinoma cell proliferation and migration through the upregulation of PAK2, among other genes. Gastrodin, another natural compound, was found to ameliorate cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation. In adnexal skin tumors, including poroma and porocarcinoma, recurrent gene fusions involving PAK2 were identified, suggesting the potential role of PAK2 in the diagnosis and prognosis of these tumors. Finally, a cross-species analysis identified mitochondrial dysregulation, including PAK2 involvement, as a functional consequence of the 3q29 deletion, a genetic risk factor for schizophrenia. These findings highlight the diverse applications of PAK2 in various conditions and provide insights into its biological significance.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Jones (Verified Customer)

What is the role of PAK2 in cancer cell tumorigenicity? Jun 08 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PAK2 is involved in cancer cell tumorigenicity, as demonstrated by the inhibition of non-small cell lung cancer (NSCLC) tumorigenesis through the miR-1287-5p/PAK2 axis. Jun 08 2022

chat Jordan Williams (Verified Customer)

Can PAK2 affect the release of von Willebrand factor? Apr 13 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, PAK2, along with septin complexes, is crucial for the actomyosin ring function and effective release of von Willebrand factor in endothelial cells. Apr 13 2021

Published Data

Fig.1 PAK2 mediates PKM2-enhanced PDAC cell metastatic potential.

In the study, they employed Western blot techniques to assess levels of PAK2 and PKM2 in AsPC-1 cells with HA-PKM2 overexpression, PAK2 knockdown, and their respective controls. Additionally, they gauged cell migration and invasion capabilities via Transwell assays, presented relative to control values.

Ref: Cheng, Tsu-Yao, et al. "Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein." Oncogene 37.13 (2018): 1730-1742.

Pubmed: 29335522

DOI: 10.1038/s41388-017-0086-y

Research Highlights

J Joseph, Chacko. et al. "Case report: Blotchy skin in a puffy neonate: is there a new association?" Frontiers in pediatrics, 2023.
Purpura fulminans is a rare yet critical condition in the neonatal population, characterized by thrombosis, vital organ necrosis, and extremity gangrene. Prompt intervention is crucial for better outcomes due to the rapidly advancing pathogenetic process. While most cases are caused by infections, it is crucial to consider other potential congenital and acquired factors. Early identification and a high index of suspicion are necessary for effective management of this condition.
J Joseph, Chacko. et al. "Case report: Blotchy skin in a puffy neonate: is there a new association?" Frontiers in pediatrics, 2023.
Pubmed: 37808560 DOI: 10.3389/fped.2023.1247343

Ma, Yu-Yang. et al. "Comprehensive genomic analysis of puerarin in inhibiting bladder urothelial carcinoma cell proliferation and migration." Recent patents on anti-cancer drug discovery, 2023.
Bladder urothelial carcinoma (BUC) is the second most common type of tumor in the urogenital system. However, there is still a need for improvement in its treatment. Puerarin, a traditional Chinese medicine, has demonstrated beneficial properties including anti-cancer, angiogenesis-promoting, and anti-inflammatory effects. This current study aims to explore the effects of puerarin on BUC and the underlying molecular mechanisms involved.
Ma, Yu-Yang. et al. "Comprehensive genomic analysis of puerarin in inhibiting bladder urothelial carcinoma cell proliferation and migration." Recent patents on anti-cancer drug discovery, 2023.
Pubmed: 37694778 DOI: 10.2174/1574892819666230908110107