mProX™ Human P2RY4 Stable Cell Line

Product Information

Target Protein

P2RY4

Target Family

P2Y Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; Cardiovascular Research

Related Diseases

Arthrogryposis; Infiltrative Basal Cell Carcinoma

Gene ID

5030

UniProt ID

P51582

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Almost all human tissues express members of the G protein-coupled P2Y receptor family, which is highly sought after as a possible treatment target for a wide range of illnesses, particularly cardiovascular and neurodegenerative disorders. Uridine 5'-triphosphate (UTP) and adenosine triphosphate (ATP) act as mediators for P2RY4 activation. P2RY4 is highly expressed throughout the body, including the heart, digestive system, skin, and central nervous system. P2RY4 is thought to control chloride secretion in the digestive system. As a result, P2RY4 antagonists are potential targets for the therapy of diarrhea, while P2RY4 agonists may be utilized to treat cystic fibrosis. Additionally, it has been suggested that P2RY4 controls how the brain produces the amyloid precursor protein (APP). P2RY4 antagonists are potential therapeutic drugs for the treatment of Alzheimer's disease since the buildup of APP in the brain is linked to the development of the condition. Although there haven't been any reports of prospective P2RY4 antagonists to date, this is a promising area for the creation of selective P2RY4 antagonists. The customized P2RY4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Liam

The customized P2RY4 stable cell line can be used in antibody discovery and development. Jan 29 2023

chat Verified Customer

chat Amelia

The P2RY4 cell line enable us to develop new insights into its role in disease pathology. Dec 01 2022

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Expression patterns of p2ry4 during early development.

From the gastrula to the tailbud stage, WISH of p2ry4. At the gastrula stage, p2ry4 was expressed throughout the developing neuroectoderm as well as the dorsal and ventral mesoderm. P2RY4 was clearly expressed in the head organizer area at stage 10.5.

Ref: Harata, Ayano, et al. "Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis." Development, Growth & Differentiation 61.2 (2019): 186-197.

Pubmed: 30069871

DOI: 10.1111/dgd.12563

Research Highlights

Vertebrates have distinctive head structures that are mostly made up of the neural crest, placode cells, and the central nervous system. The neural induction between the organizer and the potential neuroectoderm at the early gastrula stage is what first causes these head features.
Harata, Ayano, et al. "Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis." Development, Growth & Differentiation 61.2 (2019): 186-197.
Pubmed: 30069871 DOI: 10.1111/dgd.12563

In the world, hepatocellular carcinoma (HCC) is the leading cause of cancer-related death. The 5-year survival rate for HCC is remains low even though there are numerous treatment options available. Both in vitro and in vivo, emodin can stop HCC cells from proliferating.
Zhou, Rui-sheng, et al. "Anticancer effects of emodin on HepG2 cell: evidence from bioinformatic analysis." BioMed research international 2019 (2019).
Pubmed: 31236404 DOI: 10.1155/2019/3065818