mProX™ Human P2RY13 Stable Cell Line

Product Information

Target Protein

P2RY13

Target Family

P2Y Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; CNS Research

Related Diseases

Arthrogryposis; Breast Adenomyoepithelioma

Gene ID

53829

UniProt ID

Q9BPV8

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

P2Y receptors are found in a variety of organs, which suggests that they play important functions in both healthy and pathological circumstances. Along with P2RY12 and P2RY14, P2RY13 is one of the most recent P2Y receptors to be discovered. It belongs to the Gi-coupled P2Y receptor subfamily and can respond to ADP. This novel ADP receptor, which has pharmacological properties with P2RY12 receptors but has distinct properties and functions, is highlighted by pharmacology study. The signaling capabilities of P2RY13 go beyond and beyond those of a Gi-coupled receptor. Along with coupling to different G proteins, it has the ability to activate a number of intracellular pathways that are linked to the activation of the phosphatidylinositol 3-kinase axis and MAPKs. The customized P2RY13 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

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FAQ

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Published Data

Fig.1 P2ry13 mRNA

P2ry13 mRNA is not present in the neurons of the cerebral cortex (left) or cerebellum (right). P2ry13 mRNA (red) with NeuN (green; cerebral cortex) or Iba1 (green; cerebellum) double labeling. pictures with P2ry13 mRNA (top), Iba1 (middle), and overlay (bottom) are close-ups of the boxed pictures on the right.

Ref: Stefani, Jennifer, et al. "Disruption of the microglial ADP receptor P2Y13 enhances adult hippocampal neurogenesis." Frontiers in Cellular Neuroscience 12 (2018): 134.

Pubmed: 29867367

DOI: 10.3389/fncel.2018.00134

Research Highlights

By turning on the IL-6/STAT3 pathway, P2Y13 can exacerbate the breakdown of the intestinal mucosal barrier. Potential therapeutic targets for UC include P2Y13.
Wu, Xiaohan, et al. "P2RY13 exacerbates intestinal inflammation by damaging the intestinal mucosal barrier via activating IL-6/STAT3 pathway." International Journal of Biological Sciences 18.13 (2022): 5056.
Pubmed: 35982893 DOI: 10.7150/ijbs.74304

P2RY13 has a strong correlation with the TME in LUAD and may serve as a prognostic indication. To validate the current findings, however, more experimental research is needed.
Lin, Jiang, et al. "Identification of P2RY13 as an immune-related prognostic biomarker in lung adenocarcinoma: A public database-based retrospective study." PeerJ 9 (2021): e11319.
Pubmed: 33996281 DOI: 10.7717/peerj.11319