mProX™ Human P2RY1 Stable Cell Line

Product Information

Target Protein

P2RY1

Target Family

P2Y Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; Cardiovascular Research

Related Diseases

Renal Cell Carcinoma; Nonpapillary; Thrombosis

Gene ID

5028

UniProt ID

P47900

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Nucleotides such as extracellular ATP, ADP, UTP, UDP, and UDP-glucose stimulate P2RY1, which serves as a receptor. Eight P2Y receptors have so far been cloned in humans, and they play a key role in the prejunctional inhibitory control of transmitter release and cell proliferation. According to reports, P2RY1 is important for platelet physiology. In platelets, binding to ADP causes phospholipase C to be activated, mobilizing intracellular Ca2+, changing the shape of the platelet, and likely leading to platelet aggregation. According to pharmacological data, the circulating platelets include a variety of ADP-recognizing receptors, including P2RY1, P2RY12, and P2X1. On enteric neurons, P2RY1 seems to be the dominant subtype. The customized P2RY1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I am truly impressed with the performance of this P2RY1 cell line and the professionalism of Creative Biolabs. I highly recommend it to anyone. Oct 08 2022

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chat Isabella

I purchased the P2RY1 cell line from Creative Biolabs. The provided documentation was comprehensive and helped me optimize my assay conditions. Mar 28 2023

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FAQ

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Published Data

Fig.1 P2RY1 Is a Surrogate Surface Marker for PDX1

Bioinformatics anticipated that P2RY1 surface marker expression will co-localize with PDX1 in human pancreatic samples.

Ref: Qadir, Mirza Muhammad Fahd, et al. "P2RY1/ALK3-expressing cells within the adult human exocrine pancreas are BMP-7 expandable and exhibit progenitor-like characteristics." Cell reports 22.9 (2018): 2408-2420.

Pubmed: 29490276

DOI: 10.1016/j.celrep.2018.02.006

Research Highlights

The P2RY1 receptor activates the ERK signal pathway, which is known to induce cancer, although its DNA methylation state and associated regulation mechanism are yet unknown. This work profiled the genome-wide DNA methylation level in stomach cancer samples using the DNA methylation chip.
Hua, Yinggang, et al. "Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation." Open Life Sciences 18.1 (2023): 20220078.
Pubmed: 36879646 DOI: 10.1515/biol-2022-0078

In a Polish community, this study discovered a probable role for uncommon variations in the P2RY1 and P2RY12 genes implicated in platelet reactivity.
Janicki, Piotr K., et al. "Population-specific associations of deleterious rare variants in coding region of P2RY1-P2RY12 purinergic receptor genes in large-vessel ischemic stroke patients." International journal of molecular sciences 18.12 (2017): 2678.
Pubmed: 29232918 DOI: 10.3390/ijms18122678