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    mProX™ Human P2RX7 Stable Cell Line

    [CAT#: S01YF-1023-PY256]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HT22
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Infectious Research
    Related Diseases
    Tularemia; Gout
    Gene ID
    Human:5027
    UniProt ID
    Human:Q99572

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The P2RX7 gene has various applications in different fields. In the field of gastric cancer, P2RX7 is one of the genes that is hypermethylated in gastric mucosa infected with Helicobacter pylori, and its methylation is associated with specific molecular and clinicopathological features of gastric cancer. In the field of complex regional pain syndrome type 1 (CRPS-1), P2RX7 is one of the genes associated with a genetic background predisposing to the condition. In hypertension research, P2RX7 activation has been found to contribute to hypertension and cardiovascular injury by promoting immune activation, and its knockout or antagonism reduces hypertension, vascular injury, and immune cell activation. Additionally, P2RX7 has been studied in the context of chiral separation of lactam-based P2RX7 antagonists and as a target for reducing graft-versus-host disease in humanized mice.

    Protocols

    Please visit our protocols page.

    Customer Reviews

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    FAQ

    chat Taylor Jones (Verified Customer)

    How do P2RX7 polymorphisms affect receptor function? Feb 03 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Certain P2RX7 single nucleotide polymorphisms can promote exon skipping, leading to disrupted receptor function by affecting the ATP-binding site. Feb 03 2021

    chat Alex Garcia (Verified Customer)

    What is the role of P2RX7 in tumor control by CD8+ T cells? Sep 25 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Activation of P2RX7 enhances the control of melanoma by CD8+ T cells in adoptive cell therapy, indicating its importance in tumor elimination and immunotherapy. Sep 25 2021

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    • mProX™ Human P2RX7 Stable Cell Line (CAT#: S01YF-1023-PY256)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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