mProX™ Human P2RX7 Stable Cell Line
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- Membrane Protein Stable Cell Lines
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Published Data
Fig.1 P2rx7 was subdued within HT-22 cells, experiencing a knockdown.
Quantitative analysis of P2rx7 expression in P2rx7-knockdown HT-22 hippocampal neurons, which were overexpressed with Pja2, was conducted using (q)RT-PCR. The means ± SD were derived from 3 biological replicates, and a statistical significance of P < 0.01 was observed when compared to the scramble group.
Ref: Gong, Mengting, et al. "Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells." American Journal of Physiology-Cell Physiology 318.6 (2020): C1123-C1135.
Pubmed: 32267716
DOI: 10.1152/ajpcell.00070.2019
Research Highlights
Tahara, Sayumi. et al. "Helicobacter pylori infection associated DNA methylation in primary gastric cancer significantly correlates with specific molecular and clinicopathological features." Molecular carcinogenesis, 2023.
The study aimed to examine the association between Helicobacter pylori-induced DNA methylation and CpG island methylator phenotype (CIMP) in gastric cancer (GC) as well as its molecular subtypes and clinical features. A total of 624 gastric tissue samples were analyzed, including 217 primary GC, 217 adjacent mucosa, and 190 mucosae from cancer-free subjects. Five genes (IGF2, SLC16A2, SOX11, P2RX7, and MYOD1) were identified as hypermethylated in H. pylori infected gastric mucosa. Non-neoplastic mucosa from patients with GC showed higher methylation of H. pylori infection associated genes compared to those without GC. In primary GC tissues, higher methylation of these genes was correlated with CIMP-positive and related features such as MLH1 methylation. On the other hand, GC with lower methylation of these genes presented aggressive clinicopathological features. This suggests that H. pylori infection-associated DNA methylation may serve as a potential biomarker for GC.
Tahara, Sayumi. et al. "Helicobacter pylori infection associated DNA methylation in primary gastric cancer significantly correlates with specific molecular and clinicopathological features." Molecular carcinogenesis, 2023.
Pubmed:
37846801
DOI:
10.1002/mc.23650
S Shaikh, Samiha. et al. "Evidence of a genetic background predisposing to complex regional pain syndrome type 1." Journal of medical genetics, 2023.
In the current work, an exploration was conducted to analyze the genetic makeup of patients with chronic complex regional pain syndrome type 1 (CRPS-1) in comparison to those without the disorder. The study focused on the potential differences in genetic profile between the two groups. CRPS-1 is a rare and debilitating condition that frequently occurs following a physical injury. This research aimed to provide valuable insights into the genetic factors that may contribute to the development of CRPS-1.
S Shaikh, Samiha. et al. "Evidence of a genetic background predisposing to complex regional pain syndrome type 1." Journal of medical genetics, 2023.
Pubmed:
37816627
DOI:
10.1136/jmg-2023-109236
