Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. P2RX4
  3. mProX™ Human P2RX4 Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP Other Cell Lines,Drug Discovery Tools

    mProX™ Human P2RX4 Stable Cell Line

    [CAT#: S01YF-1023-PY255]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;BV-2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Pain and Addiction Research
    Related Diseases
    Anxiety; Pain Disorder
    Gene ID
    Human:5025
    UniProt ID
    Human:Q99571

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The P2RX4 gene has been identified in several studies as having potential applications in different areas. In endometrial cancer, P2RX4 is part of a cuproptosis-related gene prognostic index (CRGPI) that can estimate prognosis, immune and molecular characteristics, and treatment benefit of immunotherapy. It is associated with better overall survival, younger age, early stage, immune cell activation, high tumor mutation burden, and better response to immune checkpoint inhibitor therapy. In uveal melanoma, P2RX4 is one of the hub genes identified in a co-expressed gene network promoting CD8+ T cell infiltration. It is involved in antigen presentation and may contribute to poor prognosis. Additionally, P2RX4 has been studied in the context of chronic trigeminal neuropathic pain, where its inhibition with an HDAC5 inhibitor reverses pain-related behaviors. Overall, P2RX4 shows potential for use as a biomarker and therapeutic target in cancer and pain management.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human P2RX4 Stable Cell Line (S01YF-1023-PY255). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Jordan Miller (Verified Customer)

    Does P2RX4 play a role in Alzheimer's disease? Apr 11 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    P2RX4 receptors in microglia contribute to memory deficits in Alzheimer's disease by promoting lysosomal ApoE degradation, which indirectly affects Aβ peptide clearance and synaptic functions. Apr 11 2023

    chat Taylor Brown (Verified Customer)

    Can P2RX4 receptors influence brain necrosis and memory disorders? Aug 19 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Elevated levels of lysophosphatidylcholine (LPC) can promote radiation brain necrosis and working memory disorders through P2RX4 activation, suggesting a role in radiation therapy-induced complications. Aug 19 2020

    Related Products by Target
    • mProX™ Human P2RX4 Stable Cell Line (CAT#: S01YF-1023-PY255)
    • Magic™ Human P2RX4 HEK293 Cell Line with Photoprotein Reporter, Calcium flux assay (CAT#: S01YF-1222-KX177)
    • Magic™ mPro Human P2RX4 Cell Line (CAT#: S01YF-1122-KX126)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare