mProX™ Human OXTR Stable Cell Line

Paola Cerrito, Jeffrey K Spear "Lack of evidence for coevolution between oxytocin receptor N-terminal variants and monogamy in placental mammals." Hormones and behavior, 2023
Oxytocin (OXT) is a neurohypophyseal hormone that plays a crucial role in the regulation of affiliative behaviors, such as pair-bonding and infant care, in mammals. The effectiveness of OXT is largely dependent on its interaction with its receptor, OXTR, which is a member of the G-protein coupled receptor family. The extracellular N-terminal domain of OXTR is responsible for binding with the C-terminal tail of OXT. Interestingly, there is a significant genetic diversity in the terminal sequence of OXTR across mammalian species. Previous studies on primates have shown a correlation between OXTR phylogeny and the evolution of monogamy. However, it remains unclear if this variation co-evolved with specific mating systems or infant care behaviors. To address this question, a phylogenetic comparative and evolutionary modeling approach was applied to a diverse group of placental mammals (n = 60). The results indicate that the diversity in the N-terminal region of OXTR is not likely to be the genetic basis for the variation in affiliative behaviors as no evidence of co-evolution between protein sequence and these behaviors was found. Therefore, it is unlikely that the impact of OXT on affiliative behaviors is influenced by the genetic diversity of its receptor.
Paola Cerrito, Jeffrey K Spear "Lack of evidence for coevolution between oxytocin receptor N-terminal variants and monogamy in placental mammals." Hormones and behavior, 2023
Pubmed: 37806189   DOI: 10.1016/j.yhbeh.2023.105437

Alexey Kuznetsov et al. "Genetic Contributors to PTSD: the Role of SNVs, Gene Interactions and Haplotypes for Developing PTSD Prevention Measures. A Comprehensive Review." Psychiatria Danubina, 2023
In this study, an examination was conducted on post-traumatic stress disorder (PTSD), a mental health condition associated with high socioeconomic burden. The authors aimed to identify potential genetic markers that may predispose individuals to PTSD, with the goal of informing future research on developing preventative and remedial measures. The study involved a literature review of 547 articles from the PubMed database, of which 20 met the inclusion criteria. Results showed significant associations between PTSD and various genetic variants, such as FKBP5 rs9470080, two FKBP5 haplotypes, and certain gene-gene interactions. However, our current understanding of the complex genetic factors involved in PTSD remains limited, and further exploration of epigenetic mechanisms is needed. Future research should prioritize examining these aspects to gain a more comprehensive understanding of the disorder and its underlying genetics.
Alexey Kuznetsov et al. "Genetic Contributors to PTSD: the Role of SNVs, Gene Interactions and Haplotypes for Developing PTSD Prevention Measures. A Comprehensive Review." Psychiatria Danubina, 2023
Pubmed: 37800217   DOI: No