Oxytocin Family Related Drug Discovery Products
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From worms to humans, oxytocin (OT) has played a long-standing function in regulating social sensing and behavior. OT controls maternal behavior in addition to controlling mammalian labor and nursing. There is mounting evidence that OT affects human parenting and mediates the effects of parenting on infant socio-emotional development, promoting social recognition, mediating social reward, and enhancing signal-to-noise neurotransmission in the striatum and hippocampus. These fundamental mechanisms probably play a role in more advanced OT-mediated behaviors, such as social bonding.
Fig.1. Signal transduction for the oxytocin receptor. (Mitchell, 1998)
Creative Biolabs offers following oxytocin family drug discovery assays and related products with the best quality:
Overview of Oxytocin Family
OXTR variation modifies social context sensitivity, making those with polymorphisms that make them more susceptible to harmful social influences more at risk of developing psychopathological symptoms. For instance, it has been discovered that OXTR variations modulate the impacts of early parental care and variably affect how young people respond to their behavior. OXTR rs53576 G/G homozygotes were discovered to be the adolescents that responded to parental support and intervention the best. Male A-carriers of this polymorphism who have a history of paternal overprotection have been found to be more sensitive to social discomfort than G/G genotype carriers, as seen by higher increases in heart rate and nasal temperature variations. Studies on gene-by-environment interactions between OXTR and parental care represent a crucial area of research that could strengthen the framework of how gene and environment jointly contribute to etiologies underlying psychological disorders because early adverse experiences frequently manifest in the context of insufficient parental care.
OXTR Single Nucleotide Polymorphisms (SNPs)
Researchers have showed that, rather than inheriting the condition itself, people typically inherit genetic predispositions to a certain disorder. Gene expressions are hence the cause of the susceptibility. It is possible to extract data about approximately 5000 SNPs, which are essentially variants in genic material, on charge of a nucleotide, from the introns and exons of the gene encoding OXTR. Despite the fact that SNPs in the intronic region of the gene that codes for OXTR have no influence on OXTR functionality per se, several investigations found a link between polymorphisms and biological variations in oxytocin plasma levels. Intronic OXTR gene polymorphisms could have regulatory effects on nearby genomic areas' transcription, methylation, or altered splicing. Numerous variations have already been investigated, both within SNPs and in haploid genotypes, or sets of genes inherited together.
Fig.2. The OXTR gene. (Cataldo, 2018)
References
- Mitchell, B.F.; et al. Oxytocin: a paracrine hormone in the regulation of parturition? Reviews of reproduction. 1998, 3: 113-122.
- Cataldo, I.; et al. Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders. Research in developmental disabilities. 2018, 82: 27-38.
