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    mProX™ Human ORAI1 Stable Cell Line

    [CAT#: S01YF-1023-PY259]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HT22
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Immunology Research
    Related Diseases
    Immunodeficiency 9; Myopathy, Tubular Aggregate, 2
    Gene ID
    Human:84876
    UniProt ID
    Human:Q96D31

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ORAI1 is a calcium channel protein that plays a role in various physiological functions. It is involved in osteoblast proliferation, as well as the prevention of tubular aggregate myopathy in mice through voluntary wheel running. ORAI1 also has implications in myocardial fibrosis in type-II diabetic rats, where the use of SKF96365, an inhibitor of calcium ion entry, can improve fibrosis. Additionally, ORAI1 is part of the store-operated calcium entry (SOCE) mechanism, which regulates calcium signaling in cancer cells. It is associated with cell proliferation, migration, metastasis, apoptosis, and epithelial-mesenchymal transition in various types of cancers. The functional studies of ORAI1 have been conducted through reconstitution into liposomes and investigating its interaction with STIM1, another calcium sensor protein.

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    FAQ

    chat Taylor Smith (Verified Customer)

    How does ORAI1 interact with AKAP79 and STIM1? Sep 03 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ORAI1 interacts transiently with AKAP79, while its interaction with STIM1 is more sustained, playing a crucial role in sustaining NFAT activation at endoplasmic reticulum-plasma membrane junctions. Sep 03 2021

    chat Jordan Miller (Verified Customer)

    What is the role of ORAI1 in cytoplasmic fluidity during membrane blebbing? Aug 21 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ORAI1 signaling regulates cytoplasmic fluidity in cells undergoing membrane blebbing, which involves calcium concentration regulation in the blebs through the STIM-ORAI1 pathway. Aug 21 2023

    Related Products by Target
    • mProX™ Human ORAI1 Stable Cell Line (CAT#: S01YF-1023-PY259)
    • Magic™ Human STIM1/ORAI1 HEK293 Cell Line with Photoprotein Reporter, Calcium flux assay (CAT#: S01YF-1222-KX324)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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