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    mProX™ Human OPRL1 Stable Cell Line

    [CAT#: S01YF-0923-PY154]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    OPRL1
    Target Family
    Opioid Family
    Target Protein Species
    Human
    Host Cell Type
    PANC1;MiaPaCa2;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Pain and Addiction Research;CNS Research
    Related Diseases
    Drug Dependence;Anxiety
    Gene ID
    Human: 4987
    UniProt ID
    Human: P41146

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The OPRL1 gene encodes the nociceptin receptor, which is involved in various physiological and pathological processes. Recent studies have highlighted the epigenetic regulation of OPRL1 in the context of adverse maternal environments, suggesting its potential role in neurocognitive impairment in offspring. Furthermore, elevated methylation of OPRL1 has been observed in Alzheimer's disease, indicating its potential as a methylation biomarker for diagnosis. Another study has shown that curcumin can downregulate the expression of OPRL1 in isolated neuroglia cells, which is associated with pain relief. Additionally, methylation of OPRL1 has been linked to the effects of psychosocial stress on binge drinking in adolescents, providing insights into the epigenetic mechanisms underlying substance abuse.

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    FAQ

    chat Amy (Verified Customer)

    How does the adverse maternal environment impact the expression of OPRL1 in the hippocampus? Sep 01 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    An adverse maternal environment and a Western diet can contribute to neurocognitive impairment in male offspring through the epigenetic regulation of OPRL1, affecting its variant-specific and sex-specific expression in the hippocampus. Sep 01 2022

    chat Robert (Verified Customer)

    Is there a connection between OPRL1 methylation and Alzheimer's disease? Jul 06 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, elevated methylation of the OPRL1 gene has been suggested as a potential biomarker for the diagnosis of Alzheimer's disease, indicating a role of opioid receptor genes in the disease's development. Jul 06 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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