mProX™ Human OPN5 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Opsin 5 (OPN5) and its homologs are a group of proteins within the animal opsin family that have diverse molecular characteristics. They play a significant role in physiological functions, although their precise functions are still being explored. OPN5 and its homologs have potential applications in optogenetics, as their unique molecular features make them suitable for specialized manipulations. In the field of vision, OPN5 mediates violet light-induced expression of early growth response-1 (EGR-1) in the retina, which has implications for the prevention and treatment of myopia. Additionally, OPN5 and other neuropsins are expressed in the developing and mature retina, where they are involved in light activation and the regulation of retinal cell types. In the context of viral infections, OPN4, a splicing isoform of OPN, is differentially expressed in respiratory samples during influenza A(H1N1)pdm09 infection and progression, suggesting its potential as a biomarker for disease severity. Finally, recent evidence suggests that mammals, including humans, have extraocular light sensing capacity mediated by OPN3 and OPN5, which has implications for circadian rhythm regulation and metabolic pathways. Overall, OPN5 and its homologs have diverse applications in various fields, including optogenetics, vision, viral infections, and extraocular light sensing physiology.