mProX™ Human NTRK2 Stable Cell Line

[CAT#: S01YF-1023-PY118]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX513	Magic™ Human TRKB(NTRK2) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;Ba/F3

Target Classification

Kinase Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Obesity, Hyperphagia, And Developmental Delay; Developmental And Epileptic Encephalopathy 58

Gene ID

Human:4915

UniProt ID

Human:Q16620

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NTRK2, a gene involved in tumorigenesis, has been found to have fusion with STRN in adult soft tissue tumors. The highly selective Trk tyrosine kinases inhibitors, such as larotrectinib and entrectinib, have shown significant efficacy in treating tumors with NTRK fusions. In a case study, a patient with sarcoma harboring two STRN-NTRK2 gene fusions showed a good clinical response to larotrectinib therapy. NTRK2 fusions are less common compared to NTRK1 and NTRK3 fusions. Prompt RNA-based next-generation sequencing testing at initial diagnosis could benefit patients with soft tissue tumors harboring NTRK2 fusions. Additionally, genetic variations in the TrkB.T1 isoform of NTRK2 have been associated with somatic and psychological symptoms in individuals with irritable bowel syndrome (IBS), suggesting a potential role for NTRK2 in the pathogenesis of IBS and its comorbid conditions.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Jones (Verified Customer)

How does NTRK2 influence vascular smooth muscle cell-neuron interaction? Jul 02 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

NTRK2 may be upregulated by the transcription factor Creb3l1 in vascular neurons, promoting interaction with vascular smooth muscle cells and potentially preventing ferroptosis in neurons. Jul 02 2021

chat Skyler Johnson (Verified Customer)

What is the role of NTRK2 in glioblastoma metabolism? Jan 29 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells, suggesting a potential target for treatment. Jan 29 2023

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