mProX™ Human NR1H3 Stable Cell Line

[CAT#: S01YF-1123-KX101]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Nuclear Receptor

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Lot Number

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Product Information

Target Protein

NR1H3

Target Family

Liver X Receptor

Target Protein Species

Human

Host Cell Type

Ishikawa; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Digestive and Renal Research; Metabolic Research

Related Diseases

Multiple Sclerosis; Fatty Liver Disease

Gene ID

10062

UniProt ID

Q13133

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The NR1H3 gene in humans encodes the nuclear receptor protein known as liver X receptor alpha (LXR-alpha). The nuclear receptor superfamily's subfamily comprising the liver X receptors, LXRα and LXRβ, is responsible for regulating macrophage activity by governing transcriptional programs linked to inflammation and lipid balance. Through the action of deiodinases, they are crucial in the local activation of thyroid hormones. While LXRβ is present everywhere, the inducible LXRα is primarily expressed in the liver, adrenal gland, gut, adipose tissue, macrophages, lung, and kidney. Target genes containing LXR response elements are expressed differently by retinoid X receptors (RXRs) and ligand-activated LXRs, which form obligatory heterodimers with them. The shift from psoriatic to symptomless skin may be aided by the restoration of LXR-alpha expression or function within a psoriatic lesion. The customized NR1H3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Sharon

The NR1H3 cell line is easy to use, and the provided protocols are clear and straightforward. Sep 18 2022

chat Verified Customer

chat Amy

The human NR1H3 KD cell line is approximately lower than other brands of reagents and I got similar results. Jul 29 2020

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

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