mProX™ Human NPM1 Stable Cell Line

[CAT#: S01YF-1023-PY31]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX406	Magic™ Human NPM1-ALK in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;K562

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Acute Myeloid Leukaemia With Myelodysplasia-Related Features; Leukemia, Acute Myeloid

Gene ID

Human:4869

UniProt ID

Human:P06748

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

NPM1 is a gene that is frequently mutated in acute myeloid leukemia (AML). It is associated with specific histopathologic findings in AML, such as the presence of folded or indented nuclei. These morphological features can aid in identifying a molecular subtype of AML called leukemia cutis. Additionally, NPM1 mutations, along with other genetic alterations like FLT3-ITD and KMT2A rearrangements, are associated with rapid disease progression in AML. Immune surveillance of AML, including leukemia stem and progenitor cells, is mediated by HLA-presented antigens on these cells. The identification and validation of these antigens, including those derived from NPM1 and IDH2 mutations, can potentially enable the development of T cell-based immunotherapeutic approaches for AML. Lastly, small molecule inhibitors like NSC348884 have been found to have inhibitory and proapoptotic effects on both wild-type and NPM1-mutated AML cells, with a stronger effect observed in cells carrying the NPM1 mutation.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Morgan Garcia (Verified Customer)

What is the significance of NPM1 mutations in acute myeloid leukemia (AML)? Dec 23 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

NPM1 mutations play a crucial role in the development of AML, affecting molecular and cellular mechanisms, diagnostics, prognostics, and therapeutic approaches for patients with NPM1-mutated AML. Dec 23 2020

chat Casey Miller (Verified Customer)

How common are NPM1 mutations in adult acute myeloid leukemia? Jan 02 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

NPM1 mutations are the most common genetic alteration in adult AML, detected in about 30-35% of cases and over 50% of AML with a normal karyotype. Jan 02 2020

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