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    mProX™ Human NLRP1 Stable Cell Line

    [CAT#: S01YF-1023-PY294]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;WM35;WM115;1205Lu;Hs 294T
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Palmoplantar Carcinoma, Multiple Self-Healing; Respiratory Papillomatosis, Juvenile Recurrent, Congenital
    Gene ID
    Human:22861
    UniProt ID
    Human:Q9C000

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    NLRP1 is a biomarker implicated in the pathogenesis, diagnosis, and treatment of systemic sclerosis (SSc). It is involved in the fibrotic process of SSc and is intertwined with other biomarkers such as transforming growth factor-β (TGF-β). NLRP1 is also associated with other diseases, including ovarian cancer and pancreatic adenocarcinoma (PDAC). In ovarian cancer, a pyroptosis-related long non-coding RNA signature involving NLRP1 was identified, which can be used for prognosis and constructing a ceRNA regulatory network. In PDAC, higher pyroptosis activity mediated by NLRP1 is associated with poor prognosis and oxaliplatin resistance. Additionally, NLRP1 is highly expressed in prostate cancer and facilitates tumorigenesis by promoting the maturation and release of inflammatory cytokines. In macrophages, MafB regulates NLRP3 inflammasome activation by sustaining p62 expression. Overall, NLRP1 has diverse applications in various diseases.

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    There are currently no Customer reviews or questions for mProX™ Human NLRP1 Stable Cell Line (S01YF-1023-PY294). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Taylor Johnson (Verified Customer)

    What is the role of NLRP1 in neuronal damage? Nov 30 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NLRP1 inflammasomes are implicated in neuronal damage, as seen in conditions like Alzheimer's disease. Inhibiting NLRP1 can have protective effects against such damage. Nov 30 2020

    chat Morgan Williams (Verified Customer)

    How does NLRP1 contribute to inflammatory responses in the body? May 29 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NLRP1 is involved in inflammasome activation, leading to inflammatory responses in various conditions, including spinal cord injury and retinal ischemia/reperfusion injury. May 29 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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