mProX™ Human MRGPRX4 Stable Cell Line

[CAT#: S01YF-0923-PY112]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

MRGPRX4

Target Family

Mas-related Gene Family

Target Protein Species

Human

Host Cell Type

HTLA;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research;Digestive and Renal Research

Related Diseases

Congenital Disorder Of Glycosylation, Type Ip;Intrahepatic Cholestasis Of Pregnancy

Gene ID

Human: 117196

UniProt ID

Human: Q96LA9

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MRGPRX4, another member of the MRGPR family, has garnered attention for its role in cholestatic pruritus, a severe itching condition associated with liver diseases. Research has identified MRGPRX4 as a bile acid receptor, suggesting its involvement in mediating cholestatic itch in humans. This receptor has been targeted as a promising strategy for alleviating cholestatic itch. Moreover, the discovery that RAMP2 regulates MRGPRX4 may have implications for future drug development for cholestatic itch.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Michael (Verified Customer)

What role does MRGPRX4 play in cholestatic pruritus? Mar 22 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

MRGPRX4 is identified as a bile acid receptor that likely underlies cholestatic itch in humans. Mar 22 2021

chat Emily (Verified Customer)

How does MRGPRX4 contribute to itch sensation in cholestasis? Sep 07 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

MRGPRX4 is activated by bile acids, and its activation in sensory neurons can lead to the transmission of itch signals associated with cholestasis. Sep 07 2022

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