mProX™ Human MRGPRX2 Stable Cell Line

Suzuki Y, et al. "Ondansetron-Induced Anaphylactic Shock: An In-Depth Analysis of a Rare Adverse ." Cureus, 2023.
Ondansetron is a commonly used drug in general anesthesia, known for its effectiveness in reducing postoperative nausea and vomiting caused by anesthetics. While there are known rare side effects such as serotonin syndrome, the drug is generally considered safe. However, there have been reports of anaphylactic shock associated with ondansetron. In this study, a detailed analysis was conducted on a case of anaphylaxis triggered by ondansetron. This investigation suggests that the reaction may not be a typical type I allergic response, but rather mediated through the Mas-related G protein-coupled receptor X2 (MRGPRX2) pathway, resulting in milder symptoms of anaphylaxis. The case also highlights the importance of adrenaline and antihistamines in managing such reactions. These findings indicate the need for further research on the safety profiles of commonly used drugs like ondansetron and the potential involvement of MRGPRX2 in drug-induced hypersensitivity reactions.
Pubmed: 37664335   DOI: 10.7759/cureus.42894

Palgan K. "Mast Cells and Basophils in IgE-Independent Anaphylaxis.." International journal of molecular sciences, 2023.
Anaphylaxis is a severe and potentially fatal systemic hypersensitivity reaction that has seen a significant increase in incidence across many countries in recent decades. Common triggers for these reactions include medication, food, and Hymenoptera venoms. The activation of mast cells and basophils, as well as the release of mediators, are characteristic of anaphylactic reactions. While most research has focused on IgE-dependent reactions, this paper examines IgE-independent anaphylaxis, with a particular focus on the role of mast cells and basophils, anaphylactic mediators, risk factors, triggers, and management strategies.
Pubmed: 37628983   DOI: 10.3390/ijms241612802