mProX™ Human MRGPRE Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 MRGPRE mRNA expression in human brain.
Displayed are normalized RNA expression levels (nTPM) across 13 brain regions, with color differentiation denoting specific brain areas. The accompanying bar highlights the peak expression within the considered subregions.
Ref:
Sjöstedt, Evelina, et al. "An atlas of the protein-coding genes in the human, pig, and mouse brain." Science 367.6482 (2020): eaay5947.
Human Protein Atlas proteinatlas.org
Pubmed: 32139519
DOI: 10.1126/science.aay5947
Research Highlights
Wang W, et al. "Mediation by DNA methylation on the association of BMI and serum uric acid in ." Gene, 2023.
The relationship between obesity and hyperuricemia is well-established, although the mechanisms involved are not fully understood. In order to investigate the potential role of BMI-related DNA methylation in mediating the effects of obesity on serum uric acid levels, an epigenome-wide association analysis was carried out on 64 pairs of monozygotic twins. Further analysis using ontology enrichment tools revealed 138 CpGs as potential mediators between BMI and SUA levels. This was supported by gene expression data, which showed that BMI-related DNAm variation may partly explain the association between BMI and SUA levels. Additionally, BMI-DNAm interactions were identified for two CpGs within the VENTX gene, the expression of which was also found to be negatively associated with SUA levels.
Pubmed:
36243213
DOI:
10.1016/j.gene.2022.146957
Herrera-Luis E, et al. "Epigenome-wide association study of lung function in Latino children and youth ." Clinical epigenetics, 2022.
Previous studies on DNA methylation have linked levels at different CpG sites or regions with lung function. Additionally, genetic ancestry has been associated with lung function in Latinos but no epigenome-wide association study (EWAS) has been conducted in this population. In this research, the authors aimed to identify DNA methylation patterns associated with lung function in pediatric asthma in Latinos. The study included 250 Puerto Rican and 148 Mexican American children and young adults with asthma. Results showed five CpGs significantly associated with lung function, regulated by genetic variation in Latinos and the Biobank-based Integrative Omics Studies (BIOS) consortium. Furthermore, two differentially methylated regions in REXOC and AURKC were associated with lung function in Puerto Ricans and Mexican Americans. The findings also replicated previous associations of epigenetic markers with lung function in non-Latino populations.
Pubmed:
35033200
DOI:
10.1186/s13148-022-01227-5
