mProX™ Human MET Stable Cell Line

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MES-SA/Dx5

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research

Related Diseases

Renal Cell Carcinoma, Papillary, 1; Deafness, Autosomal Recessive 97

Gene ID

Human:4233

UniProt ID

Human:P08581

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MET (Motivational Enhancement Therapy) appears to be used in a variety of contexts. One study focused on the use of behavioural economic interventions to reduce non-attendance for healthcare appointments. These interventions aimed to persuade, nudge, and incentivize patients to attend their scheduled appointments. The most common intervention assessed in this study was the use of reminders, such as SMS, telephone, or mail reminders. Another study explored the use of protein supplementation and exercise in older adults with sarcopenic obesity. The study found that whey protein supplementation, combined with exercise training, was effective in improving sarcopenic conditions and weight status. Additionally, MET was used to assess the impact of body mass index (BMI) on the survival outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors. The study found that overweight and obese patients tended to achieve prolonged survival time with these treatments. Finally, MET was used to develop a prehospital instrument, called the Pelvic Vascular Injury Score (P-VIS), for detecting significant vascular injury in patients with pelvic fractures. The P-VIS incorporated predictive factors to assess the probability of vascular injury and guide prehospital trauma management. Overall, MET is used in a range of applications, including healthcare appointment attendance, sarcopenic obesity, cancer treatment, and trauma management.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Peyton Jones (Verified Customer)

What is the role of MET in cell proliferation? May 30 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

MET protein, a receptor tyrosine kinase, stimulates intracellular signaling for cell proliferation upon binding with its ligand, hepatocyte growth factor (HGF). May 30 2020

chat Alex Garcia (Verified Customer)

What is the significance of MET in chemotherapy resistance? Dec 10 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

MET protein, encoded by the proto-oncogene MET, plays a critical role in chemotherapy resistance, making it a focus in cancer treatment strategies. Dec 10 2020

Published Data

Fig.1 Cell viability is reduced in transient c-MET-shRNA-knockdown MDR cells.

Images of the colony-forming experiment using MES-SA/Dx5 cells. The data represent the means and standard deviations of three different experiments. *P0.05 denotes a difference between the c-MET-shRNA-knockdown MDR cells and the untreated controls. *P0.05, viability is shown as means.d. (n=3).

Ref: Hung, T. H., et al. "Knockdown of c-MET induced apoptosis in ABCB1-overexpressed multidrug-resistance cancer cell lines." Cancer gene therapy 22.5 (2015): 262-270.

Pubmed: 25908454

DOI: 10.1038/cgt.2015.15

Research Highlights

T Gabrielson, Andrew. et al. "Effectiveness of Liposomal Bupivacaine with Bupivacaine Hydrochloride vs. Bupivacaine Hydrochloride Alone as a Local Anesthetic for Children Undergoing Ambulatory Urologic Surgery: The Baby ORIOLES Randomized Clinical Trial." The Journal of urology, 2023.
The researchers aimed to investigate whether the inclusion of liposomal bupivacaine in bupivacaine hydrochloride can enhance the opioid-free rate and decrease postoperative pain levels in pediatric patients undergoing ambulatory urologic procedures. A randomized controlled trial was conducted on children, and their pain scores were assessed postoperatively. The results demonstrated a potential improvement in both opioid-free rate and postoperative pain scores with the use of liposomal bupivacaine. This study provides evidence for the potential benefit of incorporating liposomal bupivacaine in pediatric urologic surgeries.
T Gabrielson, Andrew. et al. "Effectiveness of Liposomal Bupivacaine with Bupivacaine Hydrochloride vs. Bupivacaine Hydrochloride Alone as a Local Anesthetic for Children Undergoing Ambulatory Urologic Surgery: The Baby ORIOLES Randomized Clinical Trial." The Journal of urology, 2023.
Pubmed: 37871332 DOI: 10.1097/JU.0000000000003764

Conway, Emma. et al. "Use of adapted or modified methods with people with dementia in research: A scoping review." Dementia (London, England), 2023.
The exclusion of individuals with dementia from research studies has been attributed to various factors, including methodological challenges, societal stigma, and discrimination. Therefore, it is crucial to consider the perspectives of people with dementia, taking into account their varying abilities, to gain a better understanding of their experiences. Qualitative research methods are commonly used to explore the viewpoints, lived realities, and attitudes of individuals. A scoping review was conducted to investigate the use of adapted qualitative research methods with people with dementia, including the methods used and their impact on engagement and accessibility. The review involved a search of primary studies published in English in OECD countries between 2017 and 2022, with 28 studies meeting the inclusion criteria. The studies discussed a range of adaptations to research methods, with 27 providing a rationale for these modifications. However, none of the studies assessed the impact of these adaptations on engagement or accessibility. Nevertheless, some studies reported that their methods had a positive effect on engagement. Further research is necessary to explore the impact of these adaptations on the engagement of individuals with dementia, considering their varying abilities and backgrounds.
Conway, Emma. et al. "Use of adapted or modified methods with people with dementia in research: A scoping review." Dementia (London, England), 2023.
Pubmed: 37871184 DOI: 10.1177/14713012231205610