mProX™ Human MERTK Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MERTK is a protein that plays a role in various diseases and conditions. In cholestatic liver diseases, macrophages express MERTK abundantly, suggesting its involvement in the disease pathology. In myocardial infarction, it was found that mice lacking PGRN, a protein that interacts with MERTK, showed increased mortality, cardiac fibrosis, and arrhythmia after heart attack. This suggests that MERTK and PGRN play a role in cardiac remodeling after myocardial infarction. In the context of classical swine fever virus, MERTK is identified as one of the attachment factors for the virus. Additionally, in cancer and autoimmune diseases, MERTK is involved in the regulation of myeloid cells, such as myeloid-derived suppressor cells (MDSCs) and tolerogenic dendritic cells (TolDCs), which have suppressive or tolerogenic effects on the immune system. Understanding the signaling pathways that induce MERTK expression and activity in these cells could help develop therapeutic approaches for cancer patients and autoimmune diseases. In papillary thyroid cancer, MERTK is part of potential ligand-receptor pairs involved in the interactions between fibroblasts/endothelial cells and tumor cells in the tumor microenvironment. Furthermore, MERTK is implicated in the heterogeneity of thyroid cancer and could be used as a diagnostic biomarker. Overall, MERTK has important implications in liver diseases, cardiac remodeling after myocardial infarction, viral infections, cancer, and autoimmune diseases.