mProX™ Human MAP3K11 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The gene MAP3K11 has been found to play a role in multiple applications. In the study of diagnosing atherosclerosis with rheumatoid arthritis, MAP3K11 was identified as one of six immune-related hub genes that could be used for the construction of a nomogram and for diagnostic efficacy assessment. In the treatment of childhood nephrotic syndrome, machine learning algorithms identified MAP3K11 as one of eight single-nucleotide polymorphisms (SNPs) associated with the efficacy of the drug tacrolimus. In the context of oral squamous cell carcinoma, MAP3K11 was found to facilitate autophagy activity and was correlated with malignancy of cancer cells. Additionally, in a study on cardiovascular physiology, the MLK3 CRIB domain, which includes MAP3K11, was found to be critical for regulating blood pressure, cardiac hypertrophy, and left ventricular function. Overall, these studies suggest that MAP3K11 may have applications in diagnosing atherosclerosis with rheumatoid arthritis, predicting the efficacy of drugs for childhood nephrotic syndrome, assessing malignancy in oral squamous cell carcinoma, and regulating cardiovascular physiology.