mProX™ Human MAP3K1 Stable Cell Line
[CAT#: S01YF-1123-KX291]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
MAP3K1
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
4T1; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Reproductive Research
Related Diseases
46,Xy Sex Reversal 6 and 46,Xy Partial Gonadal Dysgenesis. Among its related pathways are MyD88 dependent cascade initiated on endosome and TNFR1 Pathway
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The autosomal MAP3K1 gene in humans encodes the signal transduction enzyme mitogen-activated protein kinase kinase 1 (MAP3K1). As a ubiquitin ligase and serine/threonine kinase, MAP3K1 is essential to a network of enzymes that integrates cellular receptor responses to various mitogenic and metabolic stimuli. It is possible that the MAP3K1 kinase domain functions as a mild stimulator of IκB kinase activity. A ubiquitin-conjugating enzyme that has been loaded with ubiquitin is recruited by the MAP3K1 E3 ubiquitin ligase. The enzyme then interacts with its substrates and helps transfer ubiquitin from the enzyme to its substrates. According to genetics, MAP3K1 plays a significant role in the development of embryos, cancer, cell proliferation, migration, cytokine production, and humoral immunity. The customized MAP3K1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Jessica
The affinity is very good and I definitely recommend this MAP3K1 cell line.
Jan 13 2021
Verified Customer
Deborah
We are satisfied with this human MAP3K1 cell line and we will use it in our experimental projects.
Dec 12 2021
Verified Customer
FAQ
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