mProX™ Human LRRK2 Stable Cell Line

[CAT#: S01YF-1123-KX285]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Bulk Quote

Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Assay Types
S01YF-1122-KX1193	Magic™ Human LRRK2[I2020T] in Vitro Assay	Human	Kinase Assay
S01YF-1122-KX1194	Magic™ Human LRRK2[G2019S] in Vitro Assay	Human	Kinase Assay
S01YF-1122-KX1195	Magic™ Human LRRK2[R1441C] in Vitro Assay	Human	Kinase Assay

Product Information

Target Protein

LRRK2

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research; Reproductive Research

Related Diseases

Parkinson Disease 8, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by PTK6 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma

Gene ID

120892

UniProt ID

Q5S007

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human LRRK2 gene encodes leucine-rich repeat kinase 2 (LRRK2), a big, multifunctional kinase enzyme also referred to as dardarin and PARK8. LRRK2 belongs to the family of leucine-rich repeat kinases. Variants in this gene have been linked to a higher incidence of Crohn's and Parkinson's disease. The WD40 domain, kinase domain, RAS domain, GTPase domain, leucine-rich repeat (LRR) domain, ankyrin repeat (ANK) region, and armadillo repeats (ARM) domain are all present in the protein that is encoded by the LRRK2 gene. The protein connects with the outer membrane of the mitochondria but is mostly found in the cytoplasm. The customized LRRK2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Brian

This LRRK2 overexpression cell line is sensitive and specific. I definitely recommend this cell line. Jul 29 2020

chat Verified Customer

chat Timothy

The LRRK2 cell line was easy to use and provided excellent results in my experiments. Apr 25 2023

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Related Products by Target

Online Inquiry

Thank you for your interest in mProX™ Human LRRK2 Stable Cell Line. Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):

Estimated delivery time for your area;
Product sample or exclusive offer;
In-lab demonstration;

Creative Biolabs does not share your email address with third parties. Creative Biolabs will use your email address to confirm your identity and send you transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.