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    mProX™ Human LPAR2 Stable Cell Line

    [CAT#: S01YF-0923-PY98]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    LPAR2
    Target Family
    Lysophospholipid Family
    Target Protein Species
    Human
    Host Cell Type
    AGS;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Secretory Diarrhea;Ovarian Cancer
    Gene ID
    Human: 9170

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    LPAR2, a lysophosphatidic acid receptor, has been implicated in various cancer-related processes. In gastric cancer, LPAR2 has been shown to alter cellular energy metabolism through the LPAR2-Axin2 axis, suggesting a potential therapeutic target for this malignancy. Additionally, LPAR2 has been associated with the progression of gastric cancer through the β-catenin signaling pathway. In the context of hepatoma, berberine has been identified as a potential preventive agent, working partially through antagonizing the ATX-LPA-LPAR2-p38-leptin axis. Furthermore, LPAR2 has been linked to the prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma.

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    FAQ

    chat Timothy (Verified Customer)

    How does LPAR2 influence renal cancer progression? Mar 27 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LPAR2 has been identified as a critical factor for LPA-promoted renal cancer progression. The actions of LPAR2 in promoting renal cancer are mainly dependent on the MAPK and NF-κB activation mechanisms, which regulate the cytokine network. Mar 27 2021

    chat Laura (Verified Customer)

    What role does LPAR2 play in gastric cancer initiation and progression? Feb 21 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The LPA-LPAR2 axis mediates gastric cancer initiation and progression by increasing energy metabolism via oxidative phosphorylation and glycolysis. Targeting the LPAR2 receptor may offer a novel therapeutic approach to treat gastric cancer. Feb 21 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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