mProX™ Human LILRB2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Oncology Cell Lines
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Jordan Davis (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Casey Davis (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 The enhancement of endometrial cancer cell survival is facilitated by LILRB2.
In the analysis of apoptotic status, LILRB2-knockdown HEC-1A cells and scrambled cells were subjected to representative flow cytometry. The frequencies of apoptotic cells in panel B were quantitatively assessed. Furthermore, protein levels of LILRB2, p-SHP2, SHP2, CAMK1, p-CREB, and CREB were determined through immunoblotting in LILRB2-knockdown HEC-1A cells (shLILRB2#1-#2) and scrambled cells.
Ref: Shao, Hongfang, et al. "Immune inhibitory receptor LILRB2 is critical for the endometrial cancer progression." Biochemical and biophysical research communications 506.1 (2018): 243-250.
Pubmed: 30343889
DOI: 10.1016/j.bbrc.2018.09.114
Research Highlights
Yuan, LinHui. et al. "Identification of differential immune cells and related diagnostic genes in patients with diabetic retinopathy." Medicine, 2023.
Diabetic retinopathy (DR) is a common microvascular disorder seen in individuals with diabetes mellitus. The pathogenesis of DR is primarily attributed to the decline in retinal immunity, characterized by alterations in retinal immunosuppressive features and disruptions in the blood-retinal barrier. As such, the focus of this research is on identifying immune-related biomarkers in the retinal tissue of patients with DR. The objective of this study is to gain a better understanding of the immune mechanisms involved in the development and progression of DR.
Yuan, LinHui. et al. "Identification of differential immune cells and related diagnostic genes in patients with diabetic retinopathy." Medicine, 2023.
Pubmed:
37773794
DOI:
10.1097/MD.0000000000035331
Mei, Jinfei. et al. "Identification and characterization of the conformation and size of amyloid-β (42) oligomers targeting the receptor LilrB2." Physical chemistry chemical physics : PCCP, 2023.
In groundbreaking research, scientists have discovered how the amyloid-β 42 oligomer (AβO), a key player in Alzheimer's disease, interacts with the LilrB2 D1D2 (LDD) receptor in the brain. This interaction, which occurs with high affinity, is pivotal in altering synaptic plasticity and cognitive functions. The study delved into how different forms and sizes of AβO, including toxic and non-toxic species, as well as protofibrils, bind to the LDD receptor. It was found that the LDD receptor selectively binds to various AβO species, particularly accommodating Aβ42 dimers, trimers, and SP2 AβO in a specific manner. Interestingly, protofibrils with exposed regions also bind to the LDD receptor. The research further identified two additional binding regions on the LDD receptor, which are more likely to contribute to neurotoxicity when interacting with larger AβO species in their early aggregation stage. This comprehensive analysis of the interactions between AβO and the LDD receptor not only enhances our understanding of Alzheimer's disease at the molecular level but also opens new avenues for targeted drug development.
Mei, Jinfei. et al. "Identification and characterization of the conformation and size of amyloid-β (42) oligomers targeting the receptor LilrB2." Physical chemistry chemical physics : PCCP, 2023.
Pubmed:
37700616
DOI:
10.1039/d3cp02746e
