mProX™ Human LATS2 Stable Cell Line

[CAT#: S01YF-1123-KX281]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1189	Magic™ Human LATS2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

LATS2

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Malignant Peritoneal Mesothelioma and Malignant Pleural Mesothelioma. Among its related pathways are Epithelial to mesenchymal transition in colorectal cancer and Transcription co-factors SKI and SKIL protein partners

Gene ID

26524

UniProt ID

Q9NRM7

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The LATS2 gene in humans encodes the enzyme large tumor suppressor kinase 2 (LATS2). This gene participates in the Hippo signaling pathway, where it inactivates the effector proteins, YAP and WWTR1 (TAZ). It produces a serine/threonine protein kinase that is a member of the LATS tumor suppressor family. In both early and late metaphases as well as interphase, the protein localizes to centrosomes. It interacts with the centrosomal proteins ajuba and aurora-A and is necessary for spindle formation and gamma-tubulin accumulation at the beginning of mitosis. It may work in a positive feedback loop with p53 in response to cytoskeleton damage. It also interacts with a negative regulator of p53. It can also act as a corepressor of the expression of genes that respond to androgen. The customized LATS2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Robert

The mouse LATS2 overexpression cell line proved to be an invaluable tool in my experiments. Mar 09 2022

chat Verified Customer

chat Anthony

The LATS2 overexpression cell line I purchased was incredibly effective in my research. Jun 18 2021

chat Verified Customer

FAQ

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