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    mProX™ Human LAIR1 Stable Cell Line

    [CAT#: S01YF-1023-PY276]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Caki-2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Malaria
    Gene ID
    Human:3903
    UniProt ID
    Human:Q6GTX8

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    LAIR1, or leukocyte-associated immunoglobulin-like receptor-1, has been studied in various contexts. In osteosarcoma, LAIR1 has been found to be involved in influencing prognosis and the immune microenvironment. It has also been identified as a driver of glioma progression, promoting the expression of cyclin D1 and immunosuppressive chemokines/cytokines. In hepatocellular carcinoma, LAIR1 has been linked to oxidative stress response and identified as a predictor of early occurrence and prognosis. Additionally, LAIR1 has been studied in the context of macrophage effector function, where it was found to regulate antibody-dependent cellular phagocytosis. In gliomas, FCGR2B, a gene related to LAIR1, has been identified as a prognostic marker and immune microenvironmental marker. These findings provide insights into the role of LAIR1 and related genes in cancer progression and immune response.

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    FAQ

    chat Morgan Brown (Verified Customer)

    How does LAIR1 contribute to tumor immune suppression? Jan 29 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LAIR1 expression leads to increased CD8+ T cell exhaustion and generates resistance to PD-1/PD-L1 immunotherapy in cancer, mediated by collagen in the tumor microenvironment. Jan 29 2022

    chat Alex Williams (Verified Customer)

    Can targeting LAIR1 enhance cancer immunotherapy? Jul 18 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Blocking LAIR1 signaling in immune cells inhibits tumor development and metastasis, suggesting that targeting LAIR1 can enhance the efficacy of cancer immunotherapy. Jul 18 2023

    Related Products by Target
    • Magic™ Human LAIR1 HEK293T Cell Line (CAT#: S01YF-0123-KX323)
    • mProX™ Human LAIR1 Stable Cell Line (CAT#: S01YF-1023-PY276)
    • Magic™ Human LAIR1 CHO-K1 Cell Line (CAT#: S01YF-0123-KX207)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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