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    mProX™ Human LAG3 Stable Cell Line

    [CAT#: S01YF-1023-PY183]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;BV2
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Cardiovascular Research
    Related Diseases
    Kyphoscoliotic Heart Disease; Malaria
    Gene ID
    Human:3902
    UniProt ID
    Human:P18627

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Programmed cell death 1 ligand 2 (PDCD1LG2) is a protein that has been identified as having significant implications in immunology and oncology. It plays a crucial role in regulating T-cell activation and tolerance. The interaction between PDCD1LG2 and its receptor, PD-1, is known to inhibit T-cell activation, which can be beneficial in autoimmune diseases but detrimental in cancer as it can lead to immune evasion by tumor cells. Recent research has focused on targeting this pathway to enhance anti-tumor immunity, leading to the development of immune checkpoint inhibitors that have shown promise in treating various cancers.

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    FAQ

    chat Casey Williams (Verified Customer)

    What is the function of LAG3 in T cell regulation? May 15 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LAG3 is an immune checkpoint that plays a key role in regulating T cell function, particularly in the context of tumor immunity and autoimmunity. It can inhibit T cell activation and proliferation, contributing to immune tolerance. May 15 2023

    chat Taylor Miller (Verified Customer)

    How does LAG3 interact with other immune checkpoints in cancer? Feb 18 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LAG3 often co-expresses with other immune checkpoints like PD-1 in the tumor microenvironment. Its blockade, combined with other checkpoint inhibitors, can enhance anti-tumor immune responses. Feb 18 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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