mProX™ Human KRAS Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Silencing KRAS in NSCLC cell lines.
In KRAS-mutant cell lines, pRS-KRAS infection led to a substantial decrease in KRAS protein expression when compared to both parental and pRS control vector-infected cells. Interestingly, in H1299 cells carrying the WT KRAS variant, infections with pRS, pRS-KRAS-C12, or pRS-KRAS-V12 had no discernible impact on KRAS protein levels.
Ref: Sunaga, Noriaki, et al. "Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy." Molecular cancer therapeutics 10.2 (2011): 336-346.
Pubmed: 21306997
DOI: 10.1158/1535-7163.MCT-10-0750
Research Highlights
G Fakih, Marwan. et al. "Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C" The New England journal of medicine, 2023.
This article discusses the impact of social media on mental health, specifically focusing on the influence on body image and self-esteem among adolescents. Research has shown a strong correlation between social media use and negative self-perception and body dissatisfaction. It also explores the potential positive effects of social media, such as promoting self-expression and positive body image. The findings highlight the need for further research and intervention strategies to mitigate the negative impact of social media on adolescent mental health.
G Fakih, Marwan. et al. "Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C" The New England journal of medicine, 2023.
Pubmed:
37870968
DOI:
10.1056/NEJMoa2308795
Sánchez-Tilló, Ester. et al. "The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas." JCI insight, 2023.
In CRC patients, mutations in the KRAS and BRAF genes result in distinct progression patterns. ZEB1, a protein known for inducing an epithelial-to-mesenchymal transition (EMT), is associated with worse outcomes in most carcinomas. A study using patient samples and mouse models revealed that ZEB1 plays opposite roles in KRAS- and BRAF-mutant CRCs. While ZEB1 is linked to a poorer prognosis and more aggressive tumors in KRAS-mutant CRCs, it is associated with better outcomes and decreased EMT in BRAF-mutant CRCs. This suggests that ZEB1 may function as a tumor suppressor in BRAF-mutant CRCs and highlights the importance of considering KRAS/BRAF mutations in targeting ZEB1 and EMT in personalized therapeutic approaches.
Sánchez-Tilló, Ester. et al. "The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas." JCI insight, 2023.
Pubmed:
37870961
DOI:
10.1172/jci.insight.164629
