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    mProX™ Human KIR2DL1 Stable Cell Line

    [CAT#: S01YF-1023-PY182]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;YTS
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Chronic Nk-Cell Lymphocytosis; Behcet Syndrome
    Gene ID
    Human:3802
    UniProt ID
    Human:P43626

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The applications of KIR2DL1 include its role in gene activation and expression control, its association with COVID-19 disease risk and protective factors, its potential as a therapeutic target in glioblastoma immunotherapy, and its involvement in immune infiltration in endometriosis. In terms of gene activation, the KIR2DL1 intermediate upstream element is found to participate in gene activation and is required for efficient gene activation. In the context of COVID-19, certain HLA/KIR polymorphisms, including KIR2DL1, have been associated with disease risk and protection. In glioblastoma immunotherapy, the blockade of KIR2DL1 has been shown to attenuate the antitumor effects of expanded and activated human primary natural killer cells. Lastly, in endometriosis, KIR2DL1 is identified as one of the central genes related to immune infiltration, providing insights into the immunology and molecular mechanisms of the disease.

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    FAQ

    chat Morgan Garcia (Verified Customer)

    What is the role of KIR2DL1 in immune surveillance? Oct 27 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    KIR2DL1 is involved in the regulation of natural killer (NK) cell activity and plays a crucial role in immune surveillance, particularly in the context of cancer and viral infections. Oct 27 2023

    chat Casey Jones (Verified Customer)

    How does KIR2DL1 influence the efficacy of cancer treatments? Oct 14 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The expression and genetic variations of KIR2DL1 can influence the response to cancer treatments, including immunotherapies. It can affect NK cell-mediated cytotoxicity against tumor cells. Oct 14 2022

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    • Magic™ Human KIR2DL1 CHO-K1 Cell Line, Binding assay (CAT#: S01YF-1022-KX155)
    • mProX™ Human KIR2DL1 Stable Cell Line (CAT#: S01YF-1023-PY182)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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