mProX™ Human KCNQ5 Stable Cell Line
[CAT#: S01YF-1123-KX34]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
KCNQ5
Target Family
Kv7
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
Auditory and Otology Research; CNS Research
Related Diseases
Mental Retardation; Autosomal Dominant Non-Syndromic Intellectual Disability
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The voltage-gated delayed rectifier potassium channels Kv7.1-7.5, which encode the α-subunits, are encoded by the five members of the highly conserved KCNQ gene family, including KCNQ5. It has been demonstrated that heteromeric channels containing Kv7.3 subunits along with KV7.5 or KV7.2 produce higher K+ currents than do each of the subunits alone. KCNQ1-4 is expressed in sensory outer hair cells6, KCNQ5 is found in the brain, skeletal muscle, and blood vessels, KCNQ1 is mostly expressed in cardiac muscle and the cochlea, and KCNQ2 and -3 are primarily expressed throughout the central nervous system (CNS) and peripheral nervous system (PNS). Apart from heteromerization, native KV7 currents can also be affected by assembly with KCNE subunits; mutations in either one of these might result in deafness or cardiac arrhythmia. The customized KCNQ5 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Linda
Flow cytometry is used to verify the surface expression of the KCNQ5 protein, and qPCR is used to verify the engineering results at the mRNA level.
Jul 07 2021
Verified Customer
Patricia
The customized KCNQ5 stable cell line can be used in antibody discovery and development.
Aug 07 2022
Verified Customer
FAQ
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