mProX™ Human KCNQ1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

KV channel KCNQ1 has a variety of physiological functions. KCNQ1 supplies the cardiac action potential's delayed-rectifier IKs current when combined with the KCNE1 auxiliary protein. Heritable mutations in KCNQ1 result in loss of function or abnormal gain of function, which can induce a variety of arrhythmias, including long QT syndrome (LQTS). Conversely, KCNQ1 functions as a leak channel to help preserve ion homeostasis in epithelial cells when linked with accessory protein KCNE3. KCNQ1 conforms to the typical structural arrangement of the KV superfamily, where four VSDs, each with four transmembrane helix segments (S1-S4), flank the core homotetrameric pore domain. including other KV channels, including the Drosophila Shaker channel, each KCNQ1 VSD shows sequential activation. KCNQ1 is unique, though, in that it can conduct current when its VSDs occupy the intermediate conformation, even though Shaker and KCNQ1 can both conduct current when their VSDs adopt the activated conformation. The customized KCNQ1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.