mProX™ Human KCNK2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The KCNK2 gene in humans encodes TREK-1, a protein that is a member of the potassium channel subfamily K. K2P2.1, a lipid-gated ion channel that is a member of the two-pore-domain background potassium channel protein family, is encoded by this gene. Two homodimers combine to form this type of potassium channel, which controls the resting membrane potential by releasing potassium out of the cell. Anionic lipids, certain anesthetics, stretching of the membrane, intracellular acidosis, and heat all open the channel. For this gene, three transcript variants encoding distinct isoforms have been discovered. Mammalian neurons have mechano-gated potassium channels, among which TREK-1 is a subfamily. Both chemical and physical cues can be used to open them, and they can be gated in both ways. While TREK-1 channels are present in many different tissues, they are most prevalent in the heart and brain and are located in different kinds of neurons. The mechanosensitivity of TREK-1 channels is influenced by their C-terminal. The customized KCNK2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.