mProX™ Human KCNH3 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The voltage-gated potassium (K+) channel KCNH3 is a member of the ether-a-go-go (KCNH) family. This family of channels produces an outward current that has both transient and steady-state components that are dependent on voltage. The steady component exhibits a bell-shaped current-voltage relationship, which is also seen in the transcriptional regulator ERG, a member of the KCNH family, while the transient component possesses fast-inactivating kinetics. One of the factors influencing neuronal excitability is the genetically diverse K+ channels, which are mostly expressed in the central nervous system. Although K+ channel blockers have been shown to have therapeutic promise for improving cognitive function, it is still unknown how much each K+ channel gene contributes to cognitive processes. Thanks to a particular expression in the cell bodies of neurons with characteristic pyramidal forms, KCNH3 is broadly expressed in cerebral cortexes from layer II to layer VI. Subsequent research revealed that it is related to the human central nervous system's constrained neurons' cellular excitability. The customized KCNH3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.