mProX™ Human KCND3 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
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Published Data
Fig.1 KV4.3 currents in HEK293-NaV1.5 cells transfected with KCND3.
Typical current traces in response to voltage clamp steps to test potentials between −100 and 40 mV acquired from HEK293 cells transfected with KCND3-IRES-GFP (bottom) or IRES-GFP (top) and stably expressing NaV1.5 (HEK293-NaV1.5).
Ref: Portero, Vincent, et al. "KV4. 3 expression modulates NaV1. 5 sodium current." Frontiers in physiology 9 (2018): 178.
Pubmed: 29593552
DOI: 10.3389/fphys.2018.00178
Research Highlights
The voltage-gated potassium ion channel subfamily D member 3 (Kv4.3), a six transmembrane protein involved in the transient outward K+ current, is encoded by the gene KCND3. Both neurological and cardiovascular disorders are brought on by KCND3 defects.
Pollini, Luca, et al. "KCND3-related neurological disorders: from old to emerging clinical phenotypes." International journal of molecular sciences 21.16 (2020): 5802.
Pubmed:
32823520
DOI:
10.3390/ijms21165802
Spinocerebellar ataxia types 19 and 22 (SCA19/22) is an autosomal dominant neurodegenerative condition linked to mutations in the human voltage-gated K+ channel subunit KV 4.3-encoding KCND3 gene.
Hsiao, Cheng-Tsung, et al. "Novel SCA19/22-associated KCND3 mutations disrupt human KV4. 3 protein biosynthesis and channel gating." Human Mutation 40.11 (2019): 2088-2107.
Pubmed:
31293010
DOI:
10.1002/humu.23865
