mProX™ Human KCND2 Stable Cell Line

Product Information

Target Protein

KCND2

Target Family

Kv4

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Accession Number

NM_012281

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Early Myoclonic Encephalopathy; Developmental And Epileptic Encephalopathy

Gene ID

3751

UniProt ID

Q9NZV8

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Potassium ions are transported across the membrane in line with their electrochemical gradient by the voltage-gated potassium channel KCND2. It controls an A-type outward potassium current that rapidly deactivates, which is crucial for the repolarization phase of the action potential. Along with mediating neuronal excitability, it also controls the frequency of repetitive action potential firing, shortens the duration of action potentials, extends the latency before the first spike in a series of action potentials, and modifies the reverse transmission of action potentials from the nerve cell body to dendrite. Additionally, the circadian regularity of locomotor activity is mediated by the suprachiasmatic nucleus neurons' action potential firing, which is regulated by KCND2. According to everything mentioned above, potassium channel Kv4.2 is a crucial regulator that keeps the brain's excitatory balance in a healthy range. There is evidence linking KNCD2 deficiency to neurological conditions such as epilepsy and autism. The customized KCND2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I am happy for the service and the product. The web-page is easy to navigate in order to choose the product. Feb 23 2021

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The Human KCND2 Stable Cell Line is perfect for my research. Sep 21 2022

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FAQ

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Published Data

Fig.1 KCND2 targeting construct and the generation of Kv4.2−/− mice.

The Kv4.2 message was eliminated in the brains and hearts of Kv4.2−/− mice, as validated by Northern blot analysis of mRNA samples from the brain, heart, and liver of Kv4.2+/+, Kv4.2+/−, and Kv4.2−/− animals.

Ref: Guo, Weinong, et al. "Targeted deletion of Kv4. 2 eliminates I to, f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction." Circulation research 97.12 (2005): 1342-1350.

Pubmed: 16293790

DOI: 10.1161/01.RES.0000196559.63223.aa

Research Highlights

The purpose of the study was to look into how lung adenocarcinoma (AD) and potassium voltage-gated channel subfamily D member 2 (KCND2) are related.
Xiaobo, L. U., L. I. Kainan, and Y. A. N. G. Jianjun. "Potassium voltage-gated channel subfamily D member 2 induces an aggressive phenotype in lung adenocarcinoma." Neoplasma 68.1 (2021).
Pubmed: 32977724 DOI: 10.4149/neo_2020_200629N667

For GC patients, KCND2 overexpression is a useful predictive indicator for both overall survival and recurrence-free survival.
Wei, Hua, et al. "KCND2 upregulation might be an independent indicator of poor survival in gastric cancer." Future Oncology 14.27 (2018): 2811-2820.
Pubmed: 30051729 DOI: 10.2217/fon-2018-0418