mProX™ Human KCND2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Potassium ions are transported across the membrane in line with their electrochemical gradient by the voltage-gated potassium channel KCND2. It controls an A-type outward potassium current that rapidly deactivates, which is crucial for the repolarization phase of the action potential. Along with mediating neuronal excitability, it also controls the frequency of repetitive action potential firing, shortens the duration of action potentials, extends the latency before the first spike in a series of action potentials, and modifies the reverse transmission of action potentials from the nerve cell body to dendrite. Additionally, the circadian regularity of locomotor activity is mediated by the suprachiasmatic nucleus neurons' action potential firing, which is regulated by KCND2. According to everything mentioned above, potassium channel Kv4.2 is a crucial regulator that keeps the brain's excitatory balance in a healthy range. There is evidence linking KNCD2 deficiency to neurological conditions such as epilepsy and autism. The customized KCND2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.