mProX™ Human KCNC4 Stable Cell Line

Product Information

Target Protein

KCNC4

Target Family

Kv3

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Congenital Disorder Of Glycosylation; Spinocerebellar Ataxia

Gene ID

3749

UniProt ID

Q03721

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Kv3.4, also known as potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), is a gene found in humans. There are four subfamilies within the Drosophila Shaker gene family, which encodes voltage-gated potassium channel components. This gene is similar to the Shaw subfamily based on sequence similarities. The protein that this gene encodes is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It is a member of the delayed rectifier class of channel proteins. It produces an unusual transient voltage-dependent current, which could be crucial for the excitability of neurons. For this gene, several transcript variants encoding distinct isoforms have been discovered. The customized KCNC4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

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Published Data

Fig.1 mRNA expression levels.

Kv1.4 is expressed more frequently in the prefrontal cortex, cerebellum peduncles, pituitary, and pineal gland; Kv3.3 is expressed more frequently in the prefrontal cortex, pineal gland, pituitary, and cerebellum peduncles; Kv3.4 is expressed more frequently in the cerebellum peduncles, pituitary, prefrontal cortex, and pineal gland; Kv4.1 is expressed more frequently in the pineal gland, prefrontal cortex, pituitary, and cerebellum peduncles; Kv4.2 is expressed more frequently in the cerebellum, cerebellum, and prefrontal cortex and hypothalamus; Kv4.3 is expressed more frequently in the subthalamic nucleus, pineal gland, cerebellum peduncles, pituitary, and prefrontal cortex.

Ref: Noh, Wonjun, et al. "Transient potassium channels: therapeutic targets for brain disorders." Frontiers in cellular neuroscience 13 (2019): 265.

Pubmed: 31263403

DOI: 10.3389/fncel.2019.00265

Research Highlights

The identification of LINC01535, miR-214-3p, and KCNC4 as an effective axis that exerted a pregnant control in OS development is extremely significant for the investigation of possible therapeutic approaches for OS patients.
Yao, Xiaoke, et al. "LINC01535 promotes the development of osteosarcoma through modulating miR-214-3p/KCNC4 axis." Cancer Management and Research (2020): 5575-5585.
Pubmed: 32753970 DOI: 10.2147/CMAR.S232757

KCNE3 (MiRP2) and the skeletal muscle-expressed KCNC4 (Kv3.4) α subunit combine to generate heteromeric voltage-gated K+ channels. Though its necessity in skeletal muscle has been questioned, KCNE3 was the first gene associated with skeletal muscle K+ channel dysfunction.
King, Elizabeth C., et al. "Targeted deletion of Kcne3 impairs skeletal muscle function in mice." The FASEB Journal 31.7 (2017): 2937.
Pubmed: 28356343 DOI: 10.1096/fj.201600965RR