mProX™ Human KCNC1 Stable Cell Line

[CAT#: S01YF-1123-KX24]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Ion Channel Cell Lines

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

KCNC1

Target Family

Kv3

Target Protein Species

Human

Host Cell Type

HT; NT2; CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Epilepsy; Progressive Myoclonic; Spinocerebellar Ataxia

Gene ID

3746

UniProt ID

P48547

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Four genes make up the Kv3 subfamily: Kv3.1 (also called KCNC1), Kv3.2, Kv3.3, and Kv3.4. By alternatively splicing the 3' ends of each Kv3 gene, numerous products that differ only in their short C-terminal sequences are expressed. Alternative splicing of the 3' ends of additional K+ channel genes may play a similar role since the different C termini include or control targeting signals. Kv3-type channels are present in inhibitory GABAergic interneurons that also produce parvalbumin, a calcium-binding protein that serves as a marker for fast-spiking neurons in the neocortex, thalamus, hippocampus, and striatum. Kv3.1 channels, however, have also been found in astrocytes, T-lymphocytes, oligodendrocyte precursor cells, and NPCs in addition to neurons. The customized KCNC1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Cynthia

Very easy to use for drug screening. Aug 29 2020

chat Verified Customer

chat Ashley

Excellent service! Very reliable. Fast turnaround time. Nov 02 2021

chat Verified Customer

FAQ

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