mProX™ Human KCNA7 Stable Cell Line
[CAT#: S01YF-1123-KX21]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
KCNA7
Target Family
Kv1
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
Cardiovascular Research; CNS Research
Related Diseases
Progressive Familial Heart Block; Severe Congenital Neutropenia
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
It was discovered and isolated a novel potassium channel gene in humans. A protein with 456 amino acids is encoded by the maximum open reading frame. The murine voltage-gated potassium channel protein Kv1.7 (Kcna7), which is crucial for the repolarization of cell membranes, shares 91% of its amino acids with the expected product. The human gene has been identified as the ortholog of the mouse Kcna7 and given the name Kv1.7 (KCNA7) due to their high resemblance. A structural prediction revealed six membrane-spanning domains and a pore area typical of potassium channels. The gene is expressed preferentially in skeletal muscle, the heart, and the kidney, according to Northern expression analysis. However, other tissues, such as the liver, express it at a lower level. There was only one mRNA isoform found, and its size was approximately 4.5 kb. The customized KCNA7 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Karen
We want to stick to the same system.
Aug 11 2021
Verified Customer
Rebecca
I think this KCNA7 cell line is better than many similar products already on the market.
Nov 13 2021
Verified Customer
FAQ
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