mProX™ Human KCNA6 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
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Published Data
Fig.1 The potassium channel Kv1.6.
LacZ (β-galactosidase) expression under the Kcna6 promoter is visible in DRG cells by immunostaining. It is expressed in Kcna6lacZ/lacZ DRG Kcna6lacZ carriers but not in wild-type littermates.
Ref: Peck, Liam J., et al. "Studying independent Kcna6 knock-out mice reveals toxicity of exogenous LacZ to central nociceptor terminals and differential effects of Kv1. 6 on acute and neuropathic pain sensation." Journal of Neuroscience 41.44 (2021): 9141-9162.
Pubmed: 34544832
DOI: 10.1523/JNEUROSCI.0187-21.2021
Research Highlights
De novo nonsynonymous mutations in KCNA6 linked to neurological or other clinical characteristics are reported for the first time. Variants of the channel exhibited a consistent impact on deactivation, decelerating the pace at which the channel closed after normal activation.
Salpietro, Vincenzo, et al. "De novo KCNA6 variants with attenuated KV 1.6 channel deactivation in patients with epilepsy." Epilepsia 64.2 (2023): 443-455.
Pubmed:
36318112
DOI:
10.1111/epi.17455
Clinical data suggests that cells from the heart, brain, and sensory organs can become infected by SARS-CoV-2, even though the respiratory system is the primary site of infection. Comprehending the essential elements of viral infection in these tissues could aid in the discovery of innovative treatments.
Wang, Chengkun, et al. "CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2." bioRxiv (2021): 2021-07.
