mProX™ Human KCNA4 Stable Cell Line

Product Information

Target Protein

KCNA4

Target Family

Kv1

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research; Digestive and Renal Research

Related Diseases

Microcephaly; Cataracts; Impaired Intellectual Development; Dystonia

Gene ID

3739

UniProt ID

P22459

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Subfamily of potassium voltage-gated channels The KCNA4 gene in humans produces the protein known as A member 4 (also known as Kv1.4). It contributes to the cardiac transient outward potassium current (Ito1), which is a key current in the cardiac action potential's repolarizing phase 1. They control a variety of processes, including smooth muscle contraction, insulin secretion, neuronal excitability, neurotransmitter release, heart rate, and cell volume. It is a member of the A-type potassium current class, whose members may be crucial in controlling the fast repolarizing phase of cardiac action potentials, which may have an impact on how long they last. The customized KCNA4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Thomas

The Human KCNA4 Stable Cell Line is very good! Sep 12 2021

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chat Joseph

The KCNA4 Stable Cell Line is great for ion channel research. May 11 2023

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FAQ

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Published Data

Fig.1 Schematic illustration of KCNA4.

With only one open reading frame and two transcripts produced, only one of KCNA4's transcripts is translated into a protein. The model includes a number of domains, including superfamily domains, low complexity segments, and transmembrane helices.

Ref: Kaya, Namik, et al. "KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataract and intellectual disability." Journal of medical genetics 53.11 (2016): 786-792.

Pubmed: 27582084

DOI: 10.1136/jmedgenet-2015-103637

Research Highlights

From a structural and functional standpoint, voltage-gated potassium channels are an extremely diverse class of voltage-gated ion channels represented by very complex proteins. Many human illnesses are typically the result of these channels being deficient.
Kaya, Namik, et al. "KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataract and intellectual disability." Journal of medical genetics 53.11 (2016): 786-792.
Pubmed: 27582084 DOI: 10.1136/jmedgenet-2015-103637

Nucleoporins (Nups) are essential for cell-type-specific gene regulation, as evidence is mounting; however, it is not yet known how they regulate the expression and function of ion channel genes in the heart.
Gao, Xueting, et al. "Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity." Journal of cell science 134.18 (2021): jcs256818.
Pubmed: 34409458 DOI: 10.1242/jcs.256818