mProX™ Human KCNA3 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Kv1.3, also known as voltage-gated potassium channel, shaker-related subfamily member 3, is a protein that is produced in humans by the KCNA3 gene. Kv1.3 outward delayed rectifier currents normally start to flow at a membrane potential of about 35 mV. These currents exhibit classic cumulative inactivation as well as C-type inactivation. Kv1.3 channels are widely expressed in a variety of organs, including epithelia, B and T lymphocytes, macrophages, the olfactory bulb, and macrophages. Kv1.3 channels are located at the immunological synapse during antigen presentation and aid in the activation and proliferation of both B and T cells. They have thus been linked to autoimmune illnesses. Kv1.3 has mainly been found in the plasma membrane, but it has also been found in lymphocytes' inner mitochondrial membrane (IMM), where it aids in apoptosis. Kv1.3 has been linked to insulin sensitivity and obesity and takes involved in the insulin signaling pathway as well. The customized KCNA3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.