mProX™ Human KCNA3 Stable Cell Line

Product Information

Target Protein

KCNA3

Target Family

Kv1

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research

Related Diseases

Alzheimer Disease

Gene ID

3738

UniProt ID

P22001

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Kv1.3, also known as voltage-gated potassium channel, shaker-related subfamily member 3, is a protein that is produced in humans by the KCNA3 gene. Kv1.3 outward delayed rectifier currents normally start to flow at a membrane potential of about 35 mV. These currents exhibit classic cumulative inactivation as well as C-type inactivation. Kv1.3 channels are widely expressed in a variety of organs, including epithelia, B and T lymphocytes, macrophages, the olfactory bulb, and macrophages. Kv1.3 channels are located at the immunological synapse during antigen presentation and aid in the activation and proliferation of both B and T cells. They have thus been linked to autoimmune illnesses. Kv1.3 has mainly been found in the plasma membrane, but it has also been found in lymphocytes' inner mitochondrial membrane (IMM), where it aids in apoptosis. Kv1.3 has been linked to insulin sensitivity and obesity and takes involved in the insulin signaling pathway as well. The customized KCNA3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I customized the mouse KCNA3 cell line for my research. Sep 04 2023

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I purchased the Human KCNA3 Stable Cell Line for high-throughput drug screening. Aug 22 2021

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FAQ

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Published Data

Fig.1 Decreased voltage-gated potassium channel currents and KCNA3 expression in DS HNPs.

In the frontal cortical tissue of DS, a Western blot reveals a decrease in the expression of KCNA3, one of the voltage-gated potassium channels.

Ref: Lu, Jie, et al. "OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors." Human molecular genetics 21.10 (2012): 2330-2340.

Pubmed: 22343408

DOI: 10.1093/hmg/dds052

Research Highlights

This work aimed to explore the function of lncRNA kcna3 and its underlying mechanism in the development of colorectal cancer. RT-PCR was used to assess the expression of lncRNA kcna3 in human colorectal cancer (CRC) tissues and the surrounding non-tumor tissues.
Zhong, Xiaolin, et al. "Long noncoding RNA kcna3 inhibits the progression of colorectal carcinoma through down-regulating YAP1 expression." Biomedicine & Pharmacotherapy 107 (2018): 382-389.
Pubmed: 30099342 DOI: 10.1016/j.biopha.2018.07.118

Differentiating between multiple sclerosis (MS) varieties that grow slowly and quickly is based on the rate at which symptoms accumulate. Given that a patient's genetics might influence how quickly their condition progresses, finding genetic variations linked to accelerated disease progression could offer important information for prompt prognosis and the creation of the best possible treatment strategies.
Lioudyno, Victoria, et al. "A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis." Journal of Neuroscience Research 99.1 (2021): 200-208.
Pubmed: 32056271 DOI: 10.1002/jnr.24596