mProX™ Human KCNA2 Stable Cell Line
[CAT#: S01YF-1123-KX16]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
KCNA2
Target Family
Kv1
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
CNS Research; Digestive and Renal Research
Related Diseases
Developmental And Epileptic Encephalopathy; Agenesis Of Corpus Callosum, Cardiac, Ocular; Genital Syndrome
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
An alpha subunit of the voltage-gated potassium channel Kv1.2 is encoded by KCNA2. However, milder phenotypes with autosomal dominant inheritance have been documented, and both loss and gain of function mutations may have a phenotype involving epilepsy. It primarily exists as a de novo mutation. Variable phenotypes of KCNA2, such as progressive myoclonic epilepsy or epileptic encephalopathy, have been identified. In case series, it has been demonstrated that treatment with 4-aminopyridine at doses of 0.15-2.6 mg/kg/day results in seizure freedom in a number of patients. Even though these patients weren't seizure-free, there was a noticeable decrease in generalized tonic-clonic seizures. Patients who had only generalized tonic-clonic seizures prior to the administration of 4-aminopyridine were an exception to the therapeutic response; these patients did not benefit from a seizure response to the medication. The customized KCNA2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
David
I purchased the Human KCNA2 Stable Cell Line hoping it would meet my project requirements.
Dec 26 2022
Verified Customer
Deborah
The Human KCNA2 Stable Cell Line meets my requirement.
Mar 05 2022
Verified Customer
FAQ
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