mProX™ Human KCNA10 Stable Cell Line

[CAT#: S01YF-1123-KX22]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Ion Channel Cell Lines

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Lot Number

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Product Information

Target Protein

KCNA10

Target Family

Kv1

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Developmental And Epileptic Encephalopathy; Episodic Ataxia

Gene ID

3744

UniProt ID

Q16322

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Membrane proteins called potassium (K) channels play a key role in many physiological processes by controlling membrane potential. The most distinctive characteristic of the voltage-gated K (Kv) channel gene KCNA10, which belongs to the Shaker superfamily, is the presence of a putative cyclic nucleotide-binding (CNB) domain at the carboxy terminus. Voltage-gated K currents are mediated by the KCNA10 α subunit, which shows little steady-state inactivation. More positive depolarizations than 66 mV cause channels to open. The channel has an interesting inhibitor profile since it is sensitive to drugs that inhibit cyclic nucleotide gated cation channels, such verapamil and pimozide, in addition to being blocked by traditional K channel blockers. According to tail current data, KCNA10 has a selectivity ratio of at least 15:1 for potassium to sodium. The customized KCNA10 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Donna

The KCNA10 cell line worked very well. Sep 02 2023

chat Verified Customer

chat Charles

I customized a KCNA10 overexpression cell line and it was verified that the product meets my requirement. Nov 26 2020

chat Verified Customer

FAQ

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