mProX™ Human JAK3 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1178	Magic™ Human JAK3 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

JAK3

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research; Digestive and Renal Research; Reproductive Research

Related Diseases

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative and Nk-Cell Enteropathy. Among its related pathways are IL-9 Signaling Pathways and Interleukin-2 family signaling

Gene ID

3718

UniProt ID

P52333

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Instructions for producing a protein essential to the proper growth and operation of the immune system are provided by the JAK3 gene. The JAK3/STAT pathway is a signaling route that connects the cell's nucleus to external chemical cues. The JAK3 protein is a component of this pathway. The JAK3 protein relays signals that control the development and maturation of T lymphocytes and natural killer cells, two subtypes of white blood cells. JAK3 is also necessary for the proper maturation of B cells, which are a different kind of lymphocyte. In addition to assisting in immune system regulation, T cells, B cells, and natural killer cells combat germs, viruses, and fungus. The customized JAK3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Gary

The human JAK3 KO cell line was an indispensable tool in my research. The cell line's stability and reproducibility were outstanding. May 23 2020

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chat Nancy

The JAK3 KO cell line is of high quality and performs exceptionally well in my experiments. Apr 22 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 JAK2 and JAK3 Kinases activation in TCL cell lines.

Three TCL cell line lysates were used to immunoprecipitate JAK2 or JAK3, and the immuno-complex was then tested using a phospho-tyrosine antibody.

Ref: Han, Jing Jing, et al. "Prognostic and therapeutic significance of phosphorylated STAT3 and protein tyrosine phosphatase-6 in peripheral-T cell lymphoma." Blood cancer journal 8.11 (2018): 110.

Pubmed: 30420593

DOI: 10.1038/s41408-018-0138-8

Research Highlights

These findings indicate that the JAK/STAT pathway plays a significant role in a number of ISDs. Given the amount of epidermal JAK3 expression, topical JAK3 inhibitor research should be given significant attention as a potential treatment option for ISDs.
Alves de Medeiros, Ana Karina, et al. "JAK3 as an emerging target for topical treatment of inflammatory skin diseases." PLoS One 11.10 (2016): e0164080.
Pubmed: 27711196 DOI: 10.1371/journal.pone.0164080

Lymphoid cells produce Janus tyrosine kinase 3 (JAK3), which is important in T cell function signaling. It has been demonstrated that the creation of a selective JAK3 inhibitor may be advantageous for the management of autoimmune diseases.
Pei, Heying, et al. "Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis." Scientific Reports 8.1 (2018): 5273.
Pubmed: 29588471 DOI: 10.1038/s41598-018-23569-y