mProX™ Human ITGAE Stable Cell Line

Product Information

Target Family

Immune Checkpoint

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

Immune Checkpoint Cell Lines

Target Research Area

Cancer Research

Related Diseases

Mycosis Fungoides; Hairy Cell Leukemia

Gene ID

Human:3682

UniProt ID

Human:P38570

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The applications of ITGAE (CD103) in various studies include its role as a marker of exhausted CD8(+) tissue-resident memory T cells in hepatocellular carcinoma (HCC), its association with atopic asthma in airway epithelium, its involvement in the prognosis and immunosuppressive microenvironment of gliomas, its regulation of cytotoxic T-lymphocyte effector function and memory cell transition, and its association with patient survival in glioblastoma. These studies utilize techniques such as cytometry time-of-flight (CyTOF), bulk RNA sequencing, single-cell RNA sequencing, multiplex immunohistochemistry (mIHC), and gene expression profiling to investigate the expression and correlation of ITGAE with other markers and genes in different diseases. The findings suggest that ITGAE may serve as a potential therapeutic target and prognostic biomarker in these diseases, providing insights into the tumor microenvironment, immune response, and treatment strategies.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Skyler Garcia (Verified Customer)

What is the significance of ITGAE in immune cell differentiation? Nov 13 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

ITGAE is expressed by a subset of CD8+ T cells that infiltrate pancreatic islets before the onset of autoimmune diabetes, suggesting its role in immune cell differentiation and disease pathogenesis. Nov 13 2022

chat Skyler Williams (Verified Customer)

How does ITGAE expression influence colorectal cancer prognosis? Jun 14 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

ITGAE expression in colorectal cancer is correlated with cytotoxic T cell markers and predicts longer disease-free and overall survival, making it a potential biomarker for immune infiltration. Jun 14 2020

Published Data

Fig.1 Role of Smad in ITGAE enhancer activity.

The reporter plasmid, encompassing both the ITGAE promoter and enhancer, was introduced into 293-T cells, which had been previously subjected to pretreatment with the TGF-βR1 kinase inhibitor SB, and subsequently, these cells were cultured either in medium or in the presence of TGFβ-1.

Ref: Mokrani, M'Barka, et al. "Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes." The Journal of Immunology 192.5 (2014): 2471-2479.

Pubmed: 24477908

DOI: 10.4049/jimmunol.1302192

Research Highlights

J Y Reolo, Marie. et al. "CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma." Frontiers in immunology, 2023.
Despite recent advances in immunotherapy for hepatocellular carcinoma (HCC), there remains a need for a better understanding of the tumor microenvironment (TME) of HCC due its modest overall response rate. Prior studies have revealed that CD38 is highly present on tumor-infiltrating leukocytes (TILs) in HCC, with a particular prevalence on CD3+ and CD8+ T cells.
J Y Reolo, Marie. et al. "CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma." Frontiers in immunology, 2023.
Pubmed: 37377962 DOI: 10.3389/fimmu.2023.1182016

Kim, Soyeon. et al. "Cis- and trans-eQTM analysis reveals novel epigenetic and transcriptomic immune markers of atopic asthma in airway epithelium." The Journal of allergy and clinical immunology, 2023.
The study of expression quantitative trait methylation (eQTM) involves the identification of connections between DNA methylation markers and gene expression. Past research on eQTM in complex diseases has primarily examined cis-eQTM pairs located within 1 megabase. These analyses have revealed significant correlations between the methylation of specific DNA sequences and the expression of certain genes. These findings shed light on potential mechanisms underlying disease development and progression, and highlight the importance of DNA methylation in gene regulation.
Kim, Soyeon. et al. "Cis- and trans-eQTM analysis reveals novel epigenetic and transcriptomic immune markers of atopic asthma in airway epithelium." The Journal of allergy and clinical immunology, 2023.
Pubmed: 37271320 DOI: 10.1016/j.jaci.2023.05.018