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    mProX™ Human ITGAE Stable Cell Line

    [CAT#: S01YF-1023-PY179]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Mycosis Fungoides; Hairy Cell Leukemia
    Gene ID
    Human:3682
    UniProt ID
    Human:P38570

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The applications of ITGAE (CD103) in various studies include its role as a marker of exhausted CD8(+) tissue-resident memory T cells in hepatocellular carcinoma (HCC), its association with atopic asthma in airway epithelium, its involvement in the prognosis and immunosuppressive microenvironment of gliomas, its regulation of cytotoxic T-lymphocyte effector function and memory cell transition, and its association with patient survival in glioblastoma. These studies utilize techniques such as cytometry time-of-flight (CyTOF), bulk RNA sequencing, single-cell RNA sequencing, multiplex immunohistochemistry (mIHC), and gene expression profiling to investigate the expression and correlation of ITGAE with other markers and genes in different diseases. The findings suggest that ITGAE may serve as a potential therapeutic target and prognostic biomarker in these diseases, providing insights into the tumor microenvironment, immune response, and treatment strategies.

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    FAQ

    chat Skyler Garcia (Verified Customer)

    What is the significance of ITGAE in immune cell differentiation? Nov 13 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ITGAE is expressed by a subset of CD8+ T cells that infiltrate pancreatic islets before the onset of autoimmune diabetes, suggesting its role in immune cell differentiation and disease pathogenesis. Nov 13 2022

    chat Skyler Williams (Verified Customer)

    How does ITGAE expression influence colorectal cancer prognosis? Jun 14 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ITGAE expression in colorectal cancer is correlated with cytotoxic T cell markers and predicts longer disease-free and overall survival, making it a potential biomarker for immune infiltration. Jun 14 2020

    Related Products by Target
    • mProX™ Human ITGAE Stable Cell Line (CAT#: S01YF-1023-PY179)
    • Magic™ Human ITGAE CHO-K1 Cell Line, Binding assay (CAT#: S01YF-1022-KX149)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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