mProX™ Human IRAK4 Stable Cell Line

[CAT#: S01YF-1123-KX268]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1173	Magic™ Human IRAK4 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

IRAK4

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

Jurkat; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research

Related Diseases

Immunodeficiency 67 and Immunodeficiency 33. Among its related pathways are MyD88 dependent cascade initiated on endosome and Diseases of Immune System

Gene ID

51135

UniProt ID

Q9NWZ3

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Within the IRAK family, IRAK-4 (interleukin-1 receptor-associated kinase 4) is a protein kinase that functions by using Toll-like receptors to signal innate immune responses. T-cell receptor signaling is also supported by it. Domain structures seen in IRAK4 are comparable to those found in IRAK1, IRAK2, IRAKM, and Pelle. In contrast to IRAK1, IRAK2, and IRAKM, IRAK4 functions upstream of the other IRAKs; nevertheless, Pelle is more comparable to IRAK4 in this regard. Important clinical uses exist for IRAK4. Animals lacking IRAK-4 are totally immune to LPS challenge, although they are more vulnerable to germs and viruses. The customized IRAK4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Helen

This IRAK4 KD cell line is the best choice for laboratories wishing to minimise troubleshooting time. Sep 12 2021

chat Verified Customer

chat David

The ideal IRAK4 cell line, often used in our laboratories. Mar 02 2021

chat Verified Customer

FAQ

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