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    mProX™ Human IDO1 Stable Cell Line

    [CAT#: S01YF-1023-PY274]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;SK-OV-3
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Infectious Research
    Related Diseases
    Listeriosis; Bladder Disease
    Gene ID
    Human:3620
    UniProt ID
    Human:P14902

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    IDO1 is a tryptophan catabolic enzyme with significant implications in immunosuppression and tolerance. It plays a crucial role in the catabolism of the essential amino acid tryptophan into kynurenine, which has been associated with immunosuppressive effects. IDO1 is often upregulated in various cancers and contributes to immune escape by cancer cells. Its expression has been noted in tumor cells, dendritic cells, and other cells within the tumor microenvironment, where it assists in creating an immunosuppressive milieu favorable for tumor growth and protection against immune responses. Researchers have targeted IDO1 to reverse immunosuppression and enhance anti-tumor immunity, positioning it as a potential therapeutic target in oncology. By inhibiting IDO1, it's possible to alleviate immunosuppression and possibly synergize with other immunotherapeutic approaches for better outcomes in cancer treatment​

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human IDO1 Stable Cell Line (S01YF-1023-PY274). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Alex Jones (Verified Customer)

    What is the role of IDO1 in tumor microenvironment and immune suppression? Jul 10 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    IDO1 contributes to immune suppression in the tumor microenvironment, with its blockade leading to metabolic adaptation of tumors and increased NAD+, resulting in enhanced immune suppression. Jul 10 2021

    chat Morgan Jones (Verified Customer)

    How does IDO1 expression correlate with peripheral blood markers in lung adenocarcinoma? Jul 12 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Peripheral blood markers, particularly AMC and AEC, may predict IDO1 expression in lung adenocarcinoma specimens, indicating a potential biomarker role. Jul 12 2021

    Related Products by Target
    • Magic™ Human IDO1 HEK293T Cell Line (CAT#: S01YF-0123-KX289)
    • mProX™ Human IDO1 Stable Cell Line (CAT#: S01YF-1023-PY274)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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