mProX™ Human HTR7 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types
S01YF-1122-KX939	Magic™ Mouse HTR7 in Vitro cAMP Assay	Mouse	HEK293	cAMP Assay
S01YF-1122-KX940	Magic™ Mouse HTR7 in Vitro Radioligand Binding Assay	Mouse	HEK293	Radioligand Binding Assay
S01YF-1122-KX941	Magic™ Rat HTR7 in Vitro cAMP Assay	Rat	HEK293	cAMP Assay
S01YF-1122-KX942	Magic™ Rat HTR7 in Vitro Radioligand Binding Assay	Rat	HEK293	Radioligand Binding Assay

Product Information

Target Protein

HTR7

Target Family

5-Hydroxytryptamine Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research; Digestive and Renal Research; Ocular Research

Related Diseases

Irritable Bowel Syndrome; Oculogyric Crisis

Gene ID

3363

UniProt ID

P34969

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

In order to increase the production of the intracellular second messenger cAMP, activated HTR7 can encourage the activation of adenylate cyclase. The receptor is particularly expressed in the hippocampus, hypothalamus, and cortex of the brain. It can boost synaptogenesis in forebrain neurons, enhance dendritic spine density, and control neurotransmission. A number of biological functions, including thermoregulation, circadian rhythm, mood, learning and memory, and sleep, have been linked to HTR7, according to earlier research. As a result, HTR7 may be a viable therapeutic target for the treatment of a number of clinical diseases, including anxiety, depression, and cognitive impairments as well as sleep and circadian rhythmicity problems. Additionally, mood problems and significant cognitive deficiencies may be treated with HTR7 antagonists. Additionally, current research indicates that HTR7 controls inflammatory response. The customized HTR7 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ogden

mProX™ Human HTR7 Stable Cell Line woeded well! Jun 19 2023

chat Verified Customer

chat Dale

I purchased the cell line and it work well for my research. May 07 2023

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 5-HTR7 mRNA expression levels.

The impact of 100 mg/kg ketamine administration on 5-HTR7 mRNA expression levels in the hippocampal region. With the help of quantitative real-time PCR analysis, gene expression was found. The housekeeping gene control beta-actin was used to standardize the results.

Ref: Dincer, Busra, Zekai Halici, and Elif Cadirci. "Investigation of the Role of Stimulation and Blockade of 5-HT 7 Receptors in Ketamine Anesthesia." Journal of Molecular Neuroscience 71 (2021): 1095-1111.

Pubmed: 33200380

DOI: 10.1007/s12031-020-01732-3

Research Highlights

HTR7 serves as both a therapeutic target for laryngeal cancer and a predictor of the prognosis for people with the disease.
Sheng, Xiaoli, et al. "HTR7 promotes laryngeal cancer growth through PI3K/AKT pathway activation." Annals of Translational Medicine 9.10 (2021).
Pubmed: 34164474 DOI: 10.21037/atm-21-1069

Cannabis sativa modifies the expression of HTR1B and HTR7, which explains how users display depression/aggression traits and cognitive ability modification.
Dosumu, Oluwatosin Adebisi, et al. "Implications of Cannabis sativa on serotonin receptors 1B (HTR1B) and 7 (HTR7) genes in modulation of aggression and depression." Vegetos (2021): 1-7.